3sx0

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==Crystal structure of Dot1l in complex with a brominated SAH analog==
==Crystal structure of Dot1l in complex with a brominated SAH analog==
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<StructureSection load='3sx0' size='340' side='right' caption='[[3sx0]], [[Resolution|resolution]] 2.28&Aring;' scene=''>
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<StructureSection load='3sx0' size='340' side='right'caption='[[3sx0]], [[Resolution|resolution]] 2.28&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3sx0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SX0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SX0 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3sx0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SX0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SX0 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SX0:(2S)-2-AMINO-4-({[(2S,3S,4R,5R)-5-(4-AMINO-5-BROMO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL}SULFANYL)BUTANOIC+ACID+(NON-PREFERRED+NAME)'>SX0</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.28&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DOT1L, KIAA1814, KMT4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SX0:(2S)-2-AMINO-4-({[(2S,3S,4R,5R)-5-(4-AMINO-5-BROMO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL}SULFANYL)BUTANOIC+ACID+(NON-PREFERRED+NAME)'>SX0</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sx0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sx0 OCA], [https://pdbe.org/3sx0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sx0 RCSB], [https://www.ebi.ac.uk/pdbsum/3sx0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sx0 ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sx0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sx0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3sx0 RCSB], [http://www.ebi.ac.uk/pdbsum/3sx0 PDBsum]</span></td></tr>
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</table>
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<table>
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== Function ==
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[https://www.uniprot.org/uniprot/DOT1L_HUMAN DOT1L_HUMAN] Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA.
==See Also==
==See Also==
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*[[Histone methyltransferase|Histone methyltransferase]]
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*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Histone-lysine N-methyltransferase]]
 
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Large Structures]]
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[[Category: Bountra, C.]]
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[[Category: Arrowsmith CH]]
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[[Category: Brown, P J.]]
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[[Category: Bountra C]]
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[[Category: Edwards, A M.]]
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[[Category: Brown PJ]]
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[[Category: Li, Y.]]
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[[Category: Edwards AM]]
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[[Category: Nguyen, K T.]]
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[[Category: Li Y]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Nguyen KT]]
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[[Category: Schapira, M.]]
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[[Category: Schapira M]]
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[[Category: Smil, D.]]
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[[Category: Smil D]]
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[[Category: Tempel, W.]]
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[[Category: Tempel W]]
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[[Category: Vedadi, M.]]
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[[Category: Vedadi M]]
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[[Category: Weigelt, J.]]
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[[Category: Weigelt J]]
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[[Category: Wernimont, A K.]]
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[[Category: Wernimont AK]]
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[[Category: Yu, W.]]
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[[Category: Yu W]]
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[[Category: Epigenetic]]
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[[Category: Histone]]
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[[Category: Methyltransferase]]
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[[Category: Sgc]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics consortium]]
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[[Category: Transferase]]
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Current revision

Crystal structure of Dot1l in complex with a brominated SAH analog

PDB ID 3sx0

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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