3t2n

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==Human hepsin protease in complex with the Fab fragment of an inhibitory antibody==
==Human hepsin protease in complex with the Fab fragment of an inhibitory antibody==
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<StructureSection load='3t2n' size='340' side='right' caption='[[3t2n]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
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<StructureSection load='3t2n' size='340' side='right'caption='[[3t2n]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3t2n]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T2N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3T2N FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3t2n]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T2N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3T2N FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1z8g|1z8g]], [[1o5e|1o5e]], [[1p57|1p57]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HPN, TMPRSS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t2n OCA], [https://pdbe.org/3t2n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t2n RCSB], [https://www.ebi.ac.uk/pdbsum/3t2n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t2n ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydrolase Hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.106 3.4.21.106] </span></td></tr>
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</table>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3t2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t2n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3t2n RCSB], [http://www.ebi.ac.uk/pdbsum/3t2n PDBsum]</span></td></tr>
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== Function ==
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<table>
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[https://www.uniprot.org/uniprot/HEPS_HUMAN HEPS_HUMAN] Plays an essential role in cell growth and maintenance of cell morphology. May mediate the activating cleavage of HGF and MST1/HGFL.<ref>PMID:21875933</ref> <ref>PMID:15839837</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Allosteric antibody inhibition of human Hepsin protease.,Koschubs T, Dengl S, Duerr H, Kaluza K, Georges G, Hartl C, Jennewein S, Lanzendoerfer M, Auer J, Stern A, Huang KS, Packman K, Gubler U, Kostrewa D, Ries S, Hansen S, Kohnert U, Cramer P, Mundigl O Biochem J. 2011 Dec 2. PMID:22132769<ref>PMID:22132769</ref>
Allosteric antibody inhibition of human Hepsin protease.,Koschubs T, Dengl S, Duerr H, Kaluza K, Georges G, Hartl C, Jennewein S, Lanzendoerfer M, Auer J, Stern A, Huang KS, Packman K, Gubler U, Kostrewa D, Ries S, Hansen S, Kohnert U, Cramer P, Mundigl O Biochem J. 2011 Dec 2. PMID:22132769<ref>PMID:22132769</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3t2n" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Monoclonal Antibody|Monoclonal Antibody]]
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*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Hydrolase]]
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[[Category: Large Structures]]
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[[Category: Auer, J.]]
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[[Category: Auer J]]
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[[Category: Cramer, P.]]
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[[Category: Cramer P]]
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[[Category: Dengl, S.]]
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[[Category: Dengl S]]
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[[Category: Duerr, H.]]
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[[Category: Duerr H]]
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[[Category: Georges, G.]]
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[[Category: Georges G]]
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[[Category: Hansen, S.]]
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[[Category: Hansen S]]
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[[Category: Hartl, C.]]
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[[Category: Hartl C]]
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[[Category: Huang, K S.]]
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[[Category: Huang K-S]]
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[[Category: Jennewein, S.]]
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[[Category: Jennewein S]]
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[[Category: Kaluza, K.]]
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[[Category: Kaluza K]]
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[[Category: Kohnert, U.]]
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[[Category: Kohnert U]]
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[[Category: Koschubs, T.]]
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[[Category: Koschubs T]]
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[[Category: Kostrewa, D.]]
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[[Category: Kostrewa D]]
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[[Category: Lanzendoerfer, M.]]
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[[Category: Lanzendoerfer M]]
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[[Category: Mundigl, O.]]
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[[Category: Mundigl O]]
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[[Category: Ries, S.]]
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[[Category: Ries S]]
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[[Category: Stern, A.]]
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[[Category: Stern A]]
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[[Category: Hydrolase]]
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[[Category: Laminin-332]]
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[[Category: Pro-hgf]]
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[[Category: Srcr domain]]
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[[Category: Substrates include pro-hepsin]]
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[[Category: Transmembrane]]
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[[Category: Type ii transmembrane serine protease]]
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Current revision

Human hepsin protease in complex with the Fab fragment of an inhibitory antibody

PDB ID 3t2n

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