This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3ua8
From Proteopedia
(Difference between revisions)
| (4 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| + | |||
==Crystal Structure Analysis of a 6-Amino Quinazolinedione Sulfonamide bound to human GluR2== | ==Crystal Structure Analysis of a 6-Amino Quinazolinedione Sulfonamide bound to human GluR2== | ||
| - | <StructureSection load='3ua8' size='340' side='right' caption='[[3ua8]], [[Resolution|resolution]] 1.90Å' scene=''> | + | <StructureSection load='3ua8' size='340' side='right'caption='[[3ua8]], [[Resolution|resolution]] 1.90Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3ua8]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3ua8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UA8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UA8 FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=08W:N-METHYL-1-{3-[(METHYLSULFONYL)AMINO]-2,4-DIOXO-7-(TRIFLUOROMETHYL)-1,2,3,4-TETRAHYDROQUINAZOLIN-6-YL}-1H-IMIDAZOLE-4-CARBOXAMIDE'>08W</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=08W:N-METHYL-1-{3-[(METHYLSULFONYL)AMINO]-2,4-DIOXO-7-(TRIFLUOROMETHYL)-1,2,3,4-TETRAHYDROQUINAZOLIN-6-YL}-1H-IMIDAZOLE-4-CARBOXAMIDE'>08W</scene></td></tr> | |
| - | <tr | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ua8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ua8 OCA], [https://pdbe.org/3ua8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ua8 RCSB], [https://www.ebi.ac.uk/pdbsum/3ua8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ua8 ProSAT]</span></td></tr> |
| - | + | </table> | |
| - | <table> | + | == Function == |
| - | + | [https://www.uniprot.org/uniprot/GRIA2_HUMAN GRIA2_HUMAN] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:20614889</ref> | |
| - | = | + | |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
==See Also== | ==See Also== | ||
| - | *[[ | + | *[[Glutamate receptor 3D structures|Glutamate receptor 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
| Line 24: | Line 18: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Kallen J]] |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
Crystal Structure Analysis of a 6-Amino Quinazolinedione Sulfonamide bound to human GluR2
| |||||||||||
