3u3t

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (05:56, 13 July 2022) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 1: Line 1:
 +
==The S-SAD phased crystal structure of the ecto-domain of Death Receptor 6 (DR6)==
==The S-SAD phased crystal structure of the ecto-domain of Death Receptor 6 (DR6)==
-
<StructureSection load='3u3t' size='340' side='right' caption='[[3u3t]], [[Resolution|resolution]] 3.21&Aring;' scene=''>
+
<StructureSection load='3u3t' size='340' side='right'caption='[[3u3t]], [[Resolution|resolution]] 3.21&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[3u3t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U3T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U3T FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[3u3t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U3T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U3T FirstGlance]. <br>
-
</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3u3p|3u3p]], [[3u3q|3u3q]], [[3u3s|3u3s]], [[3u3v|3u3v]]</td></tr>
+
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3u3p|3u3p]], [[3u3q|3u3q]], [[3u3s|3u3s]], [[3u3v|3u3v]]</div></td></tr>
-
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TNFRSF21, DR6, UNQ437/PRO868 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
+
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TNFRSF21, DR6, UNQ437/PRO868 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u3t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u3t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3u3t RCSB], [http://www.ebi.ac.uk/pdbsum/3u3t PDBsum]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u3t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u3t OCA], [https://pdbe.org/3u3t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u3t RCSB], [https://www.ebi.ac.uk/pdbsum/3u3t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u3t ProSAT]</span></td></tr>
-
<table>
+
</table>
 +
== Function ==
 +
[[https://www.uniprot.org/uniprot/TNR21_HUMAN TNR21_HUMAN]] May activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 13: Line 16:
S-SAD phasing study of death receptor 6 and its solution conformation revealed by SAXS.,Ru H, Zhao L, Ding W, Jiao L, Shaw N, Liang W, Zhang L, Hung LW, Matsugaki N, Wakatsuki S, Liu ZJ Acta Crystallogr D Biol Crystallogr. 2012 May;68(Pt 5):521-30. Epub 2012 Apr 17. PMID:22525750<ref>PMID:22525750</ref>
S-SAD phasing study of death receptor 6 and its solution conformation revealed by SAXS.,Ru H, Zhao L, Ding W, Jiao L, Shaw N, Liang W, Zhang L, Hung LW, Matsugaki N, Wakatsuki S, Liu ZJ Acta Crystallogr D Biol Crystallogr. 2012 May;68(Pt 5):521-30. Epub 2012 Apr 17. PMID:22525750<ref>PMID:22525750</ref>
-
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
 +
<div class="pdbe-citations 3u3t" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[Tumor necrosis factor receptor 3D structures|Tumor necrosis factor receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Homo sapiens]]
+
[[Category: Human]]
-
[[Category: Ding, W.]]
+
[[Category: Large Structures]]
-
[[Category: Hung, L W.]]
+
[[Category: Ding, W]]
-
[[Category: Jiao, L Y.]]
+
[[Category: Hung, L W]]
-
[[Category: Liu, Z J.]]
+
[[Category: Jiao, L Y]]
-
[[Category: Matsugaki, N.]]
+
[[Category: Liu, Z J]]
-
[[Category: Ru, H.]]
+
[[Category: Matsugaki, N]]
-
[[Category: Shaw, N.]]
+
[[Category: Ru, H]]
-
[[Category: Wakatsuki, S.]]
+
[[Category: Shaw, N]]
-
[[Category: Zhang, L G.]]
+
[[Category: Wakatsuki, S]]
-
[[Category: Zhao, L X.]]
+
[[Category: Zhang, L G]]
 +
[[Category: Zhao, L X]]
[[Category: Apoptosis]]
[[Category: Apoptosis]]
[[Category: Trigger apoptosis]]
[[Category: Trigger apoptosis]]

Current revision

The S-SAD phased crystal structure of the ecto-domain of Death Receptor 6 (DR6)

PDB ID 3u3t

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3u3t"
Personal tools