3uus

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==Crystal structure of the dATP inhibited E. coli class Ia ribonucleotide reductase complex==
==Crystal structure of the dATP inhibited E. coli class Ia ribonucleotide reductase complex==
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<StructureSection load='3uus' size='340' side='right' caption='[[3uus]], [[Resolution|resolution]] 5.65&Aring;' scene=''>
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<StructureSection load='3uus' size='340' side='right'caption='[[3uus]], [[Resolution|resolution]] 5.65&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3uus]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UUS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UUS FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3uus]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UUS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UUS FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DTP:2-DEOXYADENOSINE+5-TRIPHOSPHATE'>DTP</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 5.65&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">b2234, dnaF, JW2228, nrdA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli]), b2235, ftsB, JW2229, nrdB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DTP:2-DEOXYADENOSINE+5-TRIPHOSPHATE'>DTP</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonucleoside-diphosphate_reductase Ribonucleoside-diphosphate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.4.1 1.17.4.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uus FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uus OCA], [https://pdbe.org/3uus PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uus RCSB], [https://www.ebi.ac.uk/pdbsum/3uus PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uus ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uus FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uus OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3uus RCSB], [http://www.ebi.ac.uk/pdbsum/3uus PDBsum]</span></td></tr>
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</table>
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<table>
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== Function ==
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[https://www.uniprot.org/uniprot/RIR1_ECOLI RIR1_ECOLI] Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R1 contains the binding sites for both substrates and allosteric effectors and carries out the actual reduction of the ribonucleotide. It also provides redox-active cysteines.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Structural interconversions modulate activity of Escherichia coli ribonucleotide reductase.,Ando N, Brignole EJ, Zimanyi CM, Funk MA, Yokoyama K, Asturias FJ, Stubbe J, Drennan CL Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):21046-51. Epub 2011 Dec 12. PMID:22160671<ref>PMID:22160671</ref>
Structural interconversions modulate activity of Escherichia coli ribonucleotide reductase.,Ando N, Brignole EJ, Zimanyi CM, Funk MA, Yokoyama K, Asturias FJ, Stubbe J, Drennan CL Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):21046-51. Epub 2011 Dec 12. PMID:22160671<ref>PMID:22160671</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3uus" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Ribonucleotide reductase|Ribonucleotide reductase]]
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*[[Ribonucleotide reductase 3D structures|Ribonucleotide reductase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Escherichia coli]]
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[[Category: Escherichia coli K-12]]
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[[Category: Ribonucleoside-diphosphate reductase]]
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[[Category: Large Structures]]
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[[Category: Drennan, C L.]]
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[[Category: Drennan CL]]
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[[Category: Zimanyi, C M.]]
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[[Category: Zimanyi CM]]
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[[Category: 10 stranded alpha/beta barrel]]
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[[Category: Datp bound]]
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[[Category: Di-iron]]
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[[Category: Oxidoreductase]]
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Current revision

Crystal structure of the dATP inhibited E. coli class Ia ribonucleotide reductase complex

PDB ID 3uus

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