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3u9x
From Proteopedia
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==Covalent attachment of pyridoxal-phosphate derivatives to 14-3-3 proteins== | ==Covalent attachment of pyridoxal-phosphate derivatives to 14-3-3 proteins== | ||
| - | <StructureSection load='3u9x' size='340' side='right' caption='[[3u9x]], [[Resolution|resolution]] 1.80Å' scene=''> | + | <StructureSection load='3u9x' size='340' side='right'caption='[[3u9x]], [[Resolution|resolution]] 1.80Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3u9x]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3u9x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U9X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U9X FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=LLP:2- | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3rdh|3rdh]], [[3t0l|3t0l]], [[3t0m|3t0m]], [[4dhm|4dhm]], [[4dhn|4dhn]], [[4dho|4dho]], [[4dhp|4dhp]], [[4dhq|4dhq]], [[4dhr|4dhr]], [[4dhs|4dhs]], [[4dht|4dht]], [[4dhu|4dhu]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3rdh|3rdh]], [[3t0l|3t0l]], [[3t0m|3t0m]], [[4dhm|4dhm]], [[4dhn|4dhn]], [[4dho|4dho]], [[4dhp|4dhp]], [[4dhq|4dhq]], [[4dhr|4dhr]], [[4dhs|4dhs]], [[4dht|4dht]], [[4dhu|4dhu]]</div></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HME1, NM_006142, SFN ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HME1, NM_006142, SFN ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u9x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u9x OCA], [https://pdbe.org/3u9x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u9x RCSB], [https://www.ebi.ac.uk/pdbsum/3u9x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u9x ProSAT]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN]] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression. | ||
| + | |||
| + | ==See Also== | ||
| + | *[[14-3-3 protein 3D structures|14-3-3 protein 3D structures]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Human]] |
| - | [[Category: Kohlbacher, O | + | [[Category: Large Structures]] |
| - | [[Category: Ottmann, C | + | [[Category: Kohlbacher, O]] |
| - | [[Category: Roeglin, L | + | [[Category: Ottmann, C]] |
| - | [[Category: Thiel, P | + | [[Category: Roeglin, L]] |
| + | [[Category: Thiel, P]] | ||
[[Category: 14-3-3]] | [[Category: 14-3-3]] | ||
[[Category: Adapter protein]] | [[Category: Adapter protein]] | ||
[[Category: Protein-protein interaction]] | [[Category: Protein-protein interaction]] | ||
[[Category: Signaling protein-inhibitor complex]] | [[Category: Signaling protein-inhibitor complex]] | ||
Current revision
Covalent attachment of pyridoxal-phosphate derivatives to 14-3-3 proteins
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