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3ub2

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==TIR domain of Mal/TIRAP==
==TIR domain of Mal/TIRAP==
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<StructureSection load='3ub2' size='340' side='right' caption='[[3ub2]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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<StructureSection load='3ub2' size='340' side='right'caption='[[3ub2]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3ub2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UB2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UB2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3ub2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UB2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UB2 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene><br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ub3|3ub3]], [[3ub4|3ub4]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3ub3|3ub3]], [[3ub4|3ub4]]</div></td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TIRAP, MAL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TIRAP, MAL ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ub2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ub2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ub2 RCSB], [http://www.ebi.ac.uk/pdbsum/3ub2 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ub2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ub2 OCA], [https://pdbe.org/3ub2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ub2 RCSB], [https://www.ebi.ac.uk/pdbsum/3ub2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ub2 ProSAT]</span></td></tr>
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<table>
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</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/TIRAP_HUMAN TIRAP_HUMAN]] Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6.<ref>PMID:18292575</ref> <ref>PMID:19509286</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Structural insights into TIR domain specificity of the bridging adaptor Mal in TLR4 signaling.,Lin Z, Lu J, Zhou W, Shen Y PLoS One. 2012;7(4):e34202. Epub 2012 Apr 2. PMID:22485159<ref>PMID:22485159</ref>
Structural insights into TIR domain specificity of the bridging adaptor Mal in TLR4 signaling.,Lin Z, Lu J, Zhou W, Shen Y PLoS One. 2012;7(4):e34202. Epub 2012 Apr 2. PMID:22485159<ref>PMID:22485159</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3ub2" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[TIR domain-containing adapter protein|TIR domain-containing adapter protein]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Lin, Z.]]
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[[Category: Large Structures]]
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[[Category: Shen, Y.]]
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[[Category: Lin, Z]]
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[[Category: Shen, Y]]
[[Category: Immune system]]
[[Category: Immune system]]
[[Category: Tir domain]]
[[Category: Tir domain]]
[[Category: Tlrs adaptor]]
[[Category: Tlrs adaptor]]

Current revision

TIR domain of Mal/TIRAP

PDB ID 3ub2

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