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3upu

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==Crystal structure of the T4 Phage SF1B Helicase Dda==
==Crystal structure of the T4 Phage SF1B Helicase Dda==
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<StructureSection load='3upu' size='340' side='right' caption='[[3upu]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
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<StructureSection load='3upu' size='340' side='right'caption='[[3upu]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3upu]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UPU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UPU FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3upu]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UPU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UPU FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.299&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">dda, sud ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10665 Enterobacteria phage T4])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_helicase DNA helicase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.12 3.6.4.12] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3upu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3upu OCA], [https://pdbe.org/3upu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3upu RCSB], [https://www.ebi.ac.uk/pdbsum/3upu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3upu ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3upu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3upu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3upu RCSB], [http://www.ebi.ac.uk/pdbsum/3upu PDBsum]</span></td></tr>
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</table>
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<table>
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== Function ==
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[https://www.uniprot.org/uniprot/DDA_BPT4 DDA_BPT4] DNA helicase that stimulates viral DNA replication and recombination. Plays a role in T4 DNA replication initiation by selecting and activating DNA origins. Acts by dissociating and reassociating with the DNA molecule being unwound. Unwinds DNA as a monomer in a 5'-to-3' direction at a rate of 250 bp/s and can efficiently displace proteins from the DNA.<ref>PMID:12411580</ref> <ref>PMID:18314134</ref> <ref>PMID:22504228</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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The T4 Phage SF1B Helicase Dda Is Structurally Optimized to Perform DNA Strand Separation.,He X, Byrd AK, Yun MK, Pemble CW 4th, Harrison D, Yeruva L, Dahl C, Kreuzer KN, Raney KD, White SW Structure. 2012 May 30. PMID:22658750<ref>PMID:22658750</ref>
The T4 Phage SF1B Helicase Dda Is Structurally Optimized to Perform DNA Strand Separation.,He X, Byrd AK, Yun MK, Pemble CW 4th, Harrison D, Yeruva L, Dahl C, Kreuzer KN, Raney KD, White SW Structure. 2012 May 30. PMID:22658750<ref>PMID:22658750</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3upu" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Helicase 3D structures|Helicase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: DNA helicase]]
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[[Category: Escherichia virus T4]]
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[[Category: Enterobacteria phage t4]]
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[[Category: Large Structures]]
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[[Category: He, X.]]
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[[Category: He X]]
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[[Category: IV, C W.Pemble.]]
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[[Category: Kreuzer KN]]
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[[Category: Kreuzer, K N.]]
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[[Category: Pemble IV CW]]
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[[Category: Raney, K D.]]
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[[Category: Raney KD]]
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[[Category: White, S W.]]
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[[Category: White SW]]
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[[Category: Yun, M K.]]
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[[Category: Yun MK]]
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[[Category: Coupling atp hydrolysis to dna unwinding]]
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[[Category: Hydrolase-dna complex]]
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[[Category: Pin-tower interface]]
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[[Category: Reca-like domain]]
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[[Category: Sh3 domain]]
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[[Category: Ssdna]]
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Current revision

Crystal structure of the T4 Phage SF1B Helicase Dda

PDB ID 3upu

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