3u82

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==Binding of herpes simplex virus glycoprotein D to nectin-1 exploits host cell adhesion==
==Binding of herpes simplex virus glycoprotein D to nectin-1 exploits host cell adhesion==
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<StructureSection load='3u82' size='340' side='right' caption='[[3u82]], [[Resolution|resolution]] 3.16&Aring;' scene=''>
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<StructureSection load='3u82' size='340' side='right'caption='[[3u82]], [[Resolution|resolution]] 3.16&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3u82]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_herpesvirus_1 Human herpesvirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U82 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U82 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3u82]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_1_strain_17 Human alphaherpesvirus 1 strain 17]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U82 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U82 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2c36|2c36]], [[3alp|3alp]], [[3u83|3u83]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.164&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">gD, US6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10298 Human herpesvirus 1]), PVRL1, HVEC, PRR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u82 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u82 OCA], [https://pdbe.org/3u82 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u82 RCSB], [https://www.ebi.ac.uk/pdbsum/3u82 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u82 ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u82 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u82 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3u82 RCSB], [http://www.ebi.ac.uk/pdbsum/3u82 PDBsum]</span></td></tr>
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</table>
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<table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/PVRL1_HUMAN PVRL1_HUMAN]] Zlotogora-Ogur syndrome;Cleft lip with or without cleft palate. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GD_HHV11 GD_HHV11]] Envelope glycoprotein that binds to the potential host cell entry receptors TNFRSF14/HVEM, PVRL1 and 3-O-sulfated heparan sulfate (By similarity). May trigger fusion with host membrane, by recruiting the fusion machinery composed of gB and gH/gL. [[http://www.uniprot.org/uniprot/PVRL1_HUMAN PVRL1_HUMAN]] Promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between PVRL1/nectin-1 and PVRL3/nectin-3 and between PVRL1/nectin-1 and PVRL4/nectin-4. Functions as an entry receptor for herpes simplex virus and pseudorabies virus.<ref>PMID:7721102</ref>
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[https://www.uniprot.org/uniprot/GD_HHV11 GD_HHV11] Envelope glycoprotein that binds to the potential host cell entry receptors TNFRSF14/HVEM, PVRL1 and 3-O-sulfated heparan sulfate (By similarity). May trigger fusion with host membrane, by recruiting the fusion machinery composed of gB and gH/gL.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Binding of herpes simplex virus glycoprotein D to nectin-1 exploits host cell adhesion.,Zhang N, Yan J, Lu G, Guo Z, Fan Z, Wang J, Shi Y, Qi J, Gao GF Nat Commun. 2011 Dec 6;2:577. doi: 10.1038/ncomms1571. PMID:22146396<ref>PMID:22146396</ref>
Binding of herpes simplex virus glycoprotein D to nectin-1 exploits host cell adhesion.,Zhang N, Yan J, Lu G, Guo Z, Fan Z, Wang J, Shi Y, Qi J, Gao GF Nat Commun. 2011 Dec 6;2:577. doi: 10.1038/ncomms1571. PMID:22146396<ref>PMID:22146396</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3u82" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
*[[Glycoproteins B and D|Glycoproteins B and D]]
*[[Glycoproteins B and D|Glycoproteins B and D]]
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*[[Poliovirus receptor-related protein|Poliovirus receptor-related protein]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Human herpesvirus 1]]
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[[Category: Human alphaherpesvirus 1 strain 17]]
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[[Category: Fan, Z.]]
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[[Category: Large Structures]]
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[[Category: Gao, G F.]]
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[[Category: Fan Z]]
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[[Category: Guo, Z.]]
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[[Category: Gao GF]]
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[[Category: Lu, G.]]
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[[Category: Guo Z]]
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[[Category: Qi, J.]]
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[[Category: Lu G]]
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[[Category: Shi, Y.]]
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[[Category: Qi J]]
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[[Category: Wang, J.]]
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[[Category: Shi Y]]
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[[Category: Yan, J.]]
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[[Category: Wang J]]
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[[Category: Zhang, N.]]
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[[Category: Yan J]]
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[[Category: Binding mode]]
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[[Category: Zhang N]]
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[[Category: Hsv-1 gd]]
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[[Category: Nectin-1]]
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[[Category: Nectin-1 dimerization preclusion]]
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[[Category: Viral protein-cell adhesion complex]]
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Current revision

Binding of herpes simplex virus glycoprotein D to nectin-1 exploits host cell adhesion

PDB ID 3u82

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