3ujl

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==Crystal structure of abscisic acid bound PYL2 in complex with type 2C protein phosphatase ABI2==
==Crystal structure of abscisic acid bound PYL2 in complex with type 2C protein phosphatase ABI2==
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<StructureSection load='3ujl' size='340' side='right' caption='[[3ujl]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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<StructureSection load='3ujl' size='340' side='right'caption='[[3ujl]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3ujl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UJL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UJL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3ujl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UJL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UJL FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A8S:(2Z,4E)-5-[(1S)-1-HYDROXY-2,6,6-TRIMETHYL-4-OXOCYCLOHEX-2-EN-1-YL]-3-METHYLPENTA-2,4-DIENOIC+ACID'>A8S</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ujg|3ujg]], [[3ujk|3ujk]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A8S:(2Z,4E)-5-[(1S)-1-HYDROXY-2,6,6-TRIMETHYL-4-OXOCYCLOHEX-2-EN-1-YL]-3-METHYLPENTA-2,4-DIENOIC+ACID'>A8S</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PYL2, RCAR14, At2g26040, T19L18.15 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 Arabidopsis thaliana]), ABI2, At5g57050, MHM17.19 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 Arabidopsis thaliana])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ujl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ujl OCA], [https://pdbe.org/3ujl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ujl RCSB], [https://www.ebi.ac.uk/pdbsum/3ujl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ujl ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr>
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</table>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ujl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ujl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ujl RCSB], [http://www.ebi.ac.uk/pdbsum/3ujl PDBsum]</span></td></tr>
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== Function ==
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<table>
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[https://www.uniprot.org/uniprot/PYL2_ARATH PYL2_ARATH] Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA.<ref>PMID:19898420</ref> <ref>PMID:19893533</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Molecular mimicry regulates ABA signaling by SnRK2 kinases and PP2C phosphatases.,Soon FF, Ng LM, Zhou XE, West GM, Kovach A, Tan MH, Suino-Powell KM, He Y, Xu Y, Chalmers MJ, Brunzelle JS, Zhang H, Yang H, Jiang H, Li J, Yong EL, Cutler S, Zhu JK, Griffin PR, Melcher K, Xu HE Science. 2012 Jan 6;335(6064):85-8. Epub 2011 Nov 24. PMID:22116026<ref>PMID:22116026</ref>
Molecular mimicry regulates ABA signaling by SnRK2 kinases and PP2C phosphatases.,Soon FF, Ng LM, Zhou XE, West GM, Kovach A, Tan MH, Suino-Powell KM, He Y, Xu Y, Chalmers MJ, Brunzelle JS, Zhang H, Yang H, Jiang H, Li J, Yong EL, Cutler S, Zhu JK, Griffin PR, Melcher K, Xu HE Science. 2012 Jan 6;335(6064):85-8. Epub 2011 Nov 24. PMID:22116026<ref>PMID:22116026</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3ujl" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[ABA Signaling Pathway|ABA Signaling Pathway]]
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*[[Abscisic acid receptor 3D structures|Abscisic acid receptor 3D structures]]
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*[[ABA-regulated Protein Phosphatase 2C|ABA-regulated Protein Phosphatase 2C]]
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*[[Protein phosphatase 3D structures|Protein phosphatase 3D structures]]
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*[[PYR/PYL/RCAR family of ABA receptors|PYR/PYL/RCAR family of ABA receptors]]
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*[[Protein phosphatase|Protein phosphatase]]
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== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Arabidopsis thaliana]]
[[Category: Arabidopsis thaliana]]
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[[Category: Phosphoprotein phosphatase]]
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[[Category: Large Structures]]
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[[Category: Brunzelle, J S.]]
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[[Category: Brunzelle JS]]
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[[Category: He, Y.]]
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[[Category: He Y]]
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[[Category: Kovach, A.]]
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[[Category: Kovach A]]
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[[Category: Li, J.]]
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[[Category: Li J]]
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[[Category: Melcher, K.]]
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[[Category: Melcher K]]
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[[Category: Ng, L M.]]
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[[Category: Ng L-M]]
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[[Category: Soon, F F.]]
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[[Category: Soon F-F]]
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[[Category: Suino-Powell, K M.]]
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[[Category: Suino-Powell KM]]
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[[Category: Tan, M H.E.]]
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[[Category: Tan MHE]]
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[[Category: Xu, H E.]]
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[[Category: Xu HE]]
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[[Category: Xu, Y.]]
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[[Category: Xu Y]]
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[[Category: Zhou, X E.]]
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[[Category: Zhou XE]]
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[[Category: Aba signaling]]
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[[Category: Abi2]]
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[[Category: Abscisic receptor]]
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[[Category: Protein phosphatase 2c]]
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[[Category: Pyl2]]
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[[Category: Signaling protein]]
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Current revision

Crystal structure of abscisic acid bound PYL2 in complex with type 2C protein phosphatase ABI2

PDB ID 3ujl

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