3uaq

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==Crystal Structure of the N-lobe Domain of Lactoferrin Binding Protein B (LbpB) of Moraxella bovis==
==Crystal Structure of the N-lobe Domain of Lactoferrin Binding Protein B (LbpB) of Moraxella bovis==
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<StructureSection load='3uaq' size='340' side='right' caption='[[3uaq]], [[Resolution|resolution]] 2.93&Aring;' scene=''>
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<StructureSection load='3uaq' size='340' side='right'caption='[[3uaq]], [[Resolution|resolution]] 2.93&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3uaq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Moraxella_bovis Moraxella bovis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UAQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UAQ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3uaq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Moraxella_bovis Moraxella bovis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UAQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UAQ FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LbpB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=476 Moraxella bovis])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9318&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uaq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uaq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3uaq RCSB], [http://www.ebi.ac.uk/pdbsum/3uaq PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uaq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uaq OCA], [https://pdbe.org/3uaq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uaq RCSB], [https://www.ebi.ac.uk/pdbsum/3uaq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uaq ProSAT]</span></td></tr>
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<table>
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</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/H9KVH9_MORBO H9KVH9_MORBO]
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Lactoferrin (Lf) is a bi-lobed, iron-binding protein found on mucosal surfaces and at sites of inflammation. Gram-negative pathogens from the Neisseriaceae and Moraxellaceae families are capable of using Lf as a source of iron for growth through a process mediated by a bacterial surface receptor that directly binds host Lf. This receptor consists of an integral outer membrane protein, lactoferrin binding protein A (LbpA), and a surface lipoprotein, lactoferrin binding protein B (LbpB). The N-lobe of the homologous transferrin binding protein B, TbpB, has been shown to facilitate transferrin binding in the process of iron acquisition. Currently there is little known about the role of LbpB in iron acquisition or how Lf interacts with the bacterial receptor proteins. No structural information on any LbpB or domain is available. In this study, we express and purify from Escherichia coli the full-length LbpB and the N-lobe of LbpB from the bovine pathogen Moraxella bovis for crystallization trials. We demonstrate that M. bovis LbpB binds to bovine but not human Lf. We also report the crystal structure of the N-terminal lobe of LbpB from M. bovis and compare it with the published structures of TbpB to speculate on the process of Lf mediated iron acquisition.
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Crystal structure of the N-lobe of lactoferrin binding protein B from Moraxella bovis(1).,Arutyunova E, Brooks CL, Beddek A, Mak MW, Schryvers AB, Lemieux MJ Biochem Cell Biol. 2012 Jun;90(3):351-61. Epub 2012 Feb 14. PMID:22332934<ref>PMID:22332934</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Large Structures]]
[[Category: Moraxella bovis]]
[[Category: Moraxella bovis]]
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[[Category: Arutyunova, E]]
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[[Category: Arutyunova E]]
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[[Category: Beddeck, A]]
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[[Category: Beddeck A]]
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[[Category: Brooks, C L.]]
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[[Category: Brooks CL]]
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[[Category: Lemieux, M J.]]
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[[Category: Lemieux MJ]]
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[[Category: Mak, M W.]]
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[[Category: Mak MW]]
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[[Category: Schryvers, A B.]]
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[[Category: Schryvers AB]]
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[[Category: Beta barrel]]
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[[Category: Lipoprotein]]
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[[Category: Protein binding]]
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Current revision

Crystal Structure of the N-lobe Domain of Lactoferrin Binding Protein B (LbpB) of Moraxella bovis

PDB ID 3uaq

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