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3tne
From Proteopedia
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==The crystal structure of protease Sapp1p from Candida parapsilosis in complex with the HIV protease inhibitor ritonavir== | ==The crystal structure of protease Sapp1p from Candida parapsilosis in complex with the HIV protease inhibitor ritonavir== | ||
| - | <StructureSection load='3tne' size='340' side='right' caption='[[3tne]], [[Resolution|resolution]] 2.40Å' scene=''> | + | <StructureSection load='3tne' size='340' side='right'caption='[[3tne]], [[Resolution|resolution]] 2.40Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3tne]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3tne]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_parapsilosis Candida parapsilosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TNE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TNE FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RIT:RITONAVIR'>RIT</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RIT:RITONAVIR'>RIT</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3fv3|3fv3]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3fv3|3fv3]]</div></td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Candidapepsin Candidapepsin], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.24 3.4.23.24] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tne OCA], [https://pdbe.org/3tne PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tne RCSB], [https://www.ebi.ac.uk/pdbsum/3tne PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tne ProSAT]</span></td></tr> |
| - | <table> | + | </table> |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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The crystal structure of protease Sapp1p from Candida parapsilosis in complex with the HIV protease inhibitor ritonavir.,Dostal J, Brynda J, Hruskova-Heidingsfeldova O, Pachl P, Pichova I, Rezacova P J Enzyme Inhib Med Chem. 2012 Feb;27(1):160-5. Epub 2011 Dec 6. PMID:22146051<ref>PMID:22146051</ref> | The crystal structure of protease Sapp1p from Candida parapsilosis in complex with the HIV protease inhibitor ritonavir.,Dostal J, Brynda J, Hruskova-Heidingsfeldova O, Pachl P, Pichova I, Rezacova P J Enzyme Inhib Med Chem. 2012 Feb;27(1):160-5. Epub 2011 Dec 6. PMID:22146051<ref>PMID:22146051</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
| + | <div class="pdbe-citations 3tne" style="background-color:#fffaf0;"></div> | ||
== References == | == References == | ||
<references/> | <references/> | ||
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[[Category: Candida parapsilosis]] | [[Category: Candida parapsilosis]] | ||
[[Category: Candidapepsin]] | [[Category: Candidapepsin]] | ||
| - | [[Category: Brynda, J | + | [[Category: Large Structures]] |
| - | [[Category: Dostal, J | + | [[Category: Brynda, J]] |
| - | [[Category: Hruskova-Heidingsfeldova, O | + | [[Category: Dostal, J]] |
| - | [[Category: Pachl, P | + | [[Category: Hruskova-Heidingsfeldova, O]] |
| - | [[Category: Pichova, I | + | [[Category: Pachl, P]] |
| - | [[Category: Rezacova, P | + | [[Category: Pichova, I]] |
| + | [[Category: Rezacova, P]] | ||
[[Category: Aspartic acid endopeptidase]] | [[Category: Aspartic acid endopeptidase]] | ||
[[Category: Catalytic domain]] | [[Category: Catalytic domain]] | ||
[[Category: Hydrolase-hydrolase inhibitor complex]] | [[Category: Hydrolase-hydrolase inhibitor complex]] | ||
[[Category: Ritonavir]] | [[Category: Ritonavir]] | ||
Current revision
The crystal structure of protease Sapp1p from Candida parapsilosis in complex with the HIV protease inhibitor ritonavir
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