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3tne

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==The crystal structure of protease Sapp1p from Candida parapsilosis in complex with the HIV protease inhibitor ritonavir==
==The crystal structure of protease Sapp1p from Candida parapsilosis in complex with the HIV protease inhibitor ritonavir==
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<StructureSection load='3tne' size='340' side='right' caption='[[3tne]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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<StructureSection load='3tne' size='340' side='right'caption='[[3tne]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3tne]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Candida_parapsilosis Candida parapsilosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TNE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TNE FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3tne]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_parapsilosis Candida parapsilosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TNE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TNE FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RIT:RITONAVIR'>RIT</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3fv3|3fv3]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RIT:RITONAVIR'>RIT</scene></td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Candidapepsin Candidapepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.24 3.4.23.24] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tne OCA], [https://pdbe.org/3tne PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tne RCSB], [https://www.ebi.ac.uk/pdbsum/3tne PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tne ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tne OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tne RCSB], [http://www.ebi.ac.uk/pdbsum/3tne PDBsum]</span></td></tr>
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</table>
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<table>
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== Function ==
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[https://www.uniprot.org/uniprot/CARP1_CANPA CARP1_CANPA]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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The crystal structure of protease Sapp1p from Candida parapsilosis in complex with the HIV protease inhibitor ritonavir.,Dostal J, Brynda J, Hruskova-Heidingsfeldova O, Pachl P, Pichova I, Rezacova P J Enzyme Inhib Med Chem. 2012 Feb;27(1):160-5. Epub 2011 Dec 6. PMID:22146051<ref>PMID:22146051</ref>
The crystal structure of protease Sapp1p from Candida parapsilosis in complex with the HIV protease inhibitor ritonavir.,Dostal J, Brynda J, Hruskova-Heidingsfeldova O, Pachl P, Pichova I, Rezacova P J Enzyme Inhib Med Chem. 2012 Feb;27(1):160-5. Epub 2011 Dec 6. PMID:22146051<ref>PMID:22146051</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3tne" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Candida parapsilosis]]
[[Category: Candida parapsilosis]]
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[[Category: Candidapepsin]]
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[[Category: Large Structures]]
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[[Category: Brynda, J.]]
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[[Category: Brynda J]]
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[[Category: Dostal, J.]]
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[[Category: Dostal J]]
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[[Category: Hruskova-Heidingsfeldova, O.]]
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[[Category: Hruskova-Heidingsfeldova O]]
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[[Category: Pachl, P.]]
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[[Category: Pachl P]]
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[[Category: Pichova, I.]]
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[[Category: Pichova I]]
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[[Category: Rezacova, P.]]
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[[Category: Rezacova P]]
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[[Category: Aspartic acid endopeptidase]]
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[[Category: Catalytic domain]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Ritonavir]]
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Current revision

The crystal structure of protease Sapp1p from Candida parapsilosis in complex with the HIV protease inhibitor ritonavir

PDB ID 3tne

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