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3tw4

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==Crystal Structure of Human Septin 7 GTPase Domain==
==Crystal Structure of Human Septin 7 GTPase Domain==
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<StructureSection load='3tw4' size='340' side='right' caption='[[3tw4]], [[Resolution|resolution]] 3.35&Aring;' scene=''>
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<StructureSection load='3tw4' size='340' side='right'caption='[[3tw4]], [[Resolution|resolution]] 3.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3tw4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TW4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TW4 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3tw4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TW4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TW4 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.35&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SEPT7, CDC10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tw4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tw4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tw4 RCSB], [http://www.ebi.ac.uk/pdbsum/3tw4 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tw4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tw4 OCA], [https://pdbe.org/3tw4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tw4 RCSB], [https://www.ebi.ac.uk/pdbsum/3tw4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tw4 ProSAT]</span></td></tr>
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<table>
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</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/SEPT7_HUMAN SEPT7_HUMAN] Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the kinetochore. Plays a role in ciliogenesis and collective cell movements.<ref>PMID:17803907</ref> <ref>PMID:18460473</ref>
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We describe the purification, crystallization and structure for the GTP-binding domain of human septin 7 (SEPT7G). We show that it forms filaments within the crystal lattice which employ both the G and NC interfaces, similar to those seen in the hetero-filament of SEPT2/6/7. The NC interface is considered promiscuous as it is absent from the hetero-filament. Such promiscuity could provide the potential for permuting monomers along a filament in order to generate diversity in hetero-polymers. On the other hand, our results suggest that the G and NC interfaces may be necessary but insufficient for determining correct hetero-filament assembly. STRUCTURED SUMMARY OF PROTEIN INTERACTIONS: SEPT7G and SEPT7Gbind by X-ray crystallography (View interaction). SEPT7 G and SEPT7 Gbind by molecular sieving (View interaction).
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Promiscuous interactions of human septins: The GTP binding domain of SEPT7 forms filaments within the crystal.,Serrao VH, Alessandro F, Caldas VE, Marcal RL, D'Muniz Pereira H, Thiemann OH, Garratt RC FEBS Lett. 2011 Nov 3. PMID:22064074<ref>PMID:22064074</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Alessandro, F.]]
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[[Category: Large Structures]]
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[[Category: Garratt, R C.]]
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[[Category: Alessandro F]]
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[[Category: Pereira, H M.]]
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[[Category: Garratt RC]]
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[[Category: Serrao, V H.B.]]
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[[Category: Pereira HM]]
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[[Category: Thiemann, O T]]
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[[Category: Serrao VHB]]
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[[Category: Cell cycle]]
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[[Category: Thiemann OT]]
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[[Category: Gtpase]]
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[[Category: Septin]]
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Current revision

Crystal Structure of Human Septin 7 GTPase Domain

PDB ID 3tw4

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