3zrt

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==Crystal structure of human PSD-95 PDZ1-2==
==Crystal structure of human PSD-95 PDZ1-2==
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<StructureSection load='3zrt' size='340' side='right' caption='[[3zrt]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
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<StructureSection load='3zrt' size='340' side='right'caption='[[3zrt]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3zrt]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZRT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZRT FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3zrt]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZRT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZRT FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1kef|1kef]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.398&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zrt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zrt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zrt RCSB], [http://www.ebi.ac.uk/pdbsum/3zrt PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zrt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zrt OCA], [https://pdbe.org/3zrt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zrt RCSB], [https://www.ebi.ac.uk/pdbsum/3zrt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zrt ProSAT]</span></td></tr>
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<table>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DLG4_HUMAN DLG4_HUMAN] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage.,Bach A, Clausen BH, Moller M, Vestergaard B, Chi CN, Round A, Sorensen PL, Nissen KB, Kastrup JS, Gajhede M, Jemth P, Kristensen AS, Lundstrom P, Lambertsen KL, Stromgaard K Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3317-22. Epub 2012 Feb 17. PMID:22343531<ref>PMID:22343531</ref>
A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage.,Bach A, Clausen BH, Moller M, Vestergaard B, Chi CN, Round A, Sorensen PL, Nissen KB, Kastrup JS, Gajhede M, Jemth P, Kristensen AS, Lundstrom P, Lambertsen KL, Stromgaard K Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3317-22. Epub 2012 Feb 17. PMID:22343531<ref>PMID:22343531</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3zrt" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Postsynaptic density protein 3D structures|Postsynaptic density protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Gajhede, M.]]
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[[Category: Large Structures]]
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[[Category: Kastrup, J S.]]
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[[Category: Gajhede M]]
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[[Category: Sorensen, P L.]]
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[[Category: Kastrup JS]]
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[[Category: Signaling protein]]
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[[Category: Sorensen PL]]

Current revision

Crystal structure of human PSD-95 PDZ1-2

PDB ID 3zrt

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