4aap
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==Crystal structure of JMJD5 domain of human Lysine-specific demethylase 8 (KDM8) in complex with N-oxalylglycine (NOG)== | ==Crystal structure of JMJD5 domain of human Lysine-specific demethylase 8 (KDM8) in complex with N-oxalylglycine (NOG)== | ||
| - | <StructureSection load='4aap' size='340' side='right' caption='[[4aap]], [[Resolution|resolution]] 2.60Å' scene=''> | + | <StructureSection load='4aap' size='340' side='right'caption='[[4aap]], [[Resolution|resolution]] 2.60Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4aap]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4aap]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AAP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AAP FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> |
| - | <tr><td class="sblockLbl"><b> | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OGA:N-OXALYLGLYCINE'>OGA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4aap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aap OCA], [https://pdbe.org/4aap PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4aap RCSB], [https://www.ebi.ac.uk/pdbsum/4aap PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4aap ProSAT]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/KDM8_HUMAN KDM8_HUMAN] Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation. | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Jumonji domain-containing protein 3D structures|Jumonji domain-containing protein 3D structures]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Allerston C]] |
| - | [[Category: | + | [[Category: Arrowsmith CH]] |
| - | [[Category: | + | [[Category: Bountra C]] |
| - | [[Category: | + | [[Category: Canning P]] |
| - | [[Category: Edwards | + | [[Category: Edwards A]] |
| - | [[Category: Gadhave | + | [[Category: Gadhave A]] |
| - | [[Category: Johansson | + | [[Category: Johansson C]] |
| - | [[Category: Krojer | + | [[Category: Krojer T]] |
| - | [[Category: Oppermann | + | [[Category: Oppermann U]] |
| - | [[Category: Vollmar | + | [[Category: Vollmar M]] |
| - | [[Category: Weigelt | + | [[Category: Weigelt J]] |
| - | [[Category: | + | [[Category: Von Delft F]] |
Current revision
Crystal structure of JMJD5 domain of human Lysine-specific demethylase 8 (KDM8) in complex with N-oxalylglycine (NOG)
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Categories: Homo sapiens | Large Structures | Allerston C | Arrowsmith CH | Bountra C | Canning P | Edwards A | Gadhave A | Johansson C | Krojer T | Oppermann U | Vollmar M | Weigelt J | Von Delft F
