4aqy

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==Structure of ribsome-apramycin complexes==
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<StructureSection load='4aqy' size='340' side='right' caption='[[4aqy]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
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==Structure of ribosome-apramycin complexes==
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<StructureSection load='4aqy' size='340' side='right'caption='[[4aqy]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4aqy]] is a 23 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AQY FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4aqy]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AQY FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AM2:APRAMYCIN'>AM2</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ab3|1ab3]], [[1an7|1an7]], [[1cqm|1cqm]], [[1cqn|1cqn]], [[1dv4|1dv4]], [[1eg0|1eg0]], [[1emw|1emw]], [[1fjg|1fjg]], [[1fka|1fka]], [[1gix|1gix]], [[1hnw|1hnw]], [[1hnx|1hnx]], [[1hnz|1hnz]], [[1hr0|1hr0]], [[1i94|1i94]], [[1i95|1i95]], [[1i96|1i96]], [[1i97|1i97]], [[1ibk|1ibk]], [[1ibl|1ibl]], [[1ibm|1ibm]], [[1j5e|1j5e]], [[1jgo|1jgo]], [[1jgp|1jgp]], [[1jgq|1jgq]], [[1kuq|1kuq]], [[1l1u|1l1u]], [[1lou|1lou]], [[1mvr|1mvr]], [[1n32|1n32]], [[1n33|1n33]], [[1n34|1n34]], [[1n36|1n36]], [[1pns|1pns]], [[1pnx|1pnx]], [[1qd7|1qd7]], [[1qjh|1qjh]], [[1qkf|1qkf]], [[1qkh|1qkh]], [[1ris|1ris]], [[1rss|1rss]], [[1twt|1twt]], [[1vox|1vox]], [[1voz|1voz]], [[1xmo|1xmo]], [[1xmq|1xmq]], [[1xnq|1xnq]], [[1xnr|1xnr]], [[1yl4|1yl4]], [[2b64|2b64]], [[2b9m|2b9m]], [[2b9o|2b9o]], [[2bvz|2bvz]], [[2bxj|2bxj]], [[2f4v|2f4v]], [[2j00|2j00]], [[2j02|2j02]], [[2jl7|2jl7]], [[2uu9|2uu9]], [[2uua|2uua]], [[2uub|2uub]], [[2uuc|2uuc]], [[2uxb|2uxb]], [[2uxc|2uxc]], [[2uxd|2uxd]], [[2v46|2v46]], [[2v48|2v48]], [[2vqe|2vqe]], [[2vqf|2vqf]], [[2wdg|2wdg]], [[2wdh|2wdh]], [[2wdk|2wdk]], [[2wdm|2wdm]], [[2wh1|2wh1]], [[2wh3|2wh3]], [[2wrn|2wrn]], [[2wrq|2wrq]], [[2x9r|2x9r]], [[2x9t|2x9t]], [[2xfz|2xfz]], [[2xg1|2xg1]], [[2xqd|2xqd]], [[2xsy|2xsy]], [[2xuy|2xuy]], [[2y0u|2y0u]], [[2y0w|2y0w]], [[2y0y|2y0y]], [[2y10|2y10]], [[2y12|2y12]], [[2y14|2y14]], [[2y18|2y18]], [[3zvo|3zvo]], [[4abr|4abr]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AM2:APRAMYCIN'>AM2</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4aqy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aqy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4aqy RCSB], [http://www.ebi.ac.uk/pdbsum/4aqy PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4aqy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aqy OCA], [https://pdbe.org/4aqy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4aqy RCSB], [https://www.ebi.ac.uk/pdbsum/4aqy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4aqy ProSAT]</span></td></tr>
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<table>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RS2_THET8 RS2_THET8] Spans the head-body hinge region of the 30S subunit. Is loosely associated with the 30S subunit.[HAMAP-Rule:MF_00291_B]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Dissociation of antibacterial activity and aminoglycoside ototoxicity in the 4-monosubstituted 2-deoxystreptamine apramycin.,Matt T, Ng CL, Lang K, Sha SH, Akbergenov R, Shcherbakov D, Meyer M, Duscha S, Xie J, Dubbaka SR, Perez-Fernandez D, Vasella A, Ramakrishnan V, Schacht J, Bottger EC Proc Natl Acad Sci U S A. 2012 Jul 3;109(27):10984-9. Epub 2012 Jun 14. PMID:22699498<ref>PMID:22699498</ref>
Dissociation of antibacterial activity and aminoglycoside ototoxicity in the 4-monosubstituted 2-deoxystreptamine apramycin.,Matt T, Ng CL, Lang K, Sha SH, Akbergenov R, Shcherbakov D, Meyer M, Duscha S, Xie J, Dubbaka SR, Perez-Fernandez D, Vasella A, Ramakrishnan V, Schacht J, Bottger EC Proc Natl Acad Sci U S A. 2012 Jul 3;109(27):10984-9. Epub 2012 Jun 14. PMID:22699498<ref>PMID:22699498</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4aqy" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Ribosomal protein THX|Ribosomal protein THX]]
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*[[Ribosomal protein THX 3D structures|Ribosomal protein THX 3D structures]]
*[[Ribosome 3D structures|Ribosome 3D structures]]
*[[Ribosome 3D structures|Ribosome 3D structures]]
== References ==
== References ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Large Structures]]
[[Category: Thermus thermophilus]]
[[Category: Thermus thermophilus]]
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[[Category: Akbergenov, R.]]
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[[Category: Akbergenov R]]
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[[Category: Bottger, E C.]]
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[[Category: Bottger EC]]
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[[Category: Dubbaka, S R.]]
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[[Category: Dubbaka SR]]
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[[Category: Duscha, S.]]
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[[Category: Duscha S]]
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[[Category: Lang, K.]]
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[[Category: Lang K]]
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[[Category: Matt, T.]]
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[[Category: Matt T]]
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[[Category: Meyer, M.]]
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[[Category: Meyer M]]
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[[Category: Ng, C L.]]
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[[Category: Ng CL]]
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[[Category: Perez-Fernandez, D.]]
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[[Category: Perez-Fernandez D]]
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[[Category: Ramakrishnan, V.]]
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[[Category: Ramakrishnan V]]
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[[Category: Schacht, J.]]
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[[Category: Schacht J]]
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[[Category: Sha, S H.]]
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[[Category: Sha SH]]
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[[Category: Shcherbakov, D.]]
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[[Category: Shcherbakov D]]
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[[Category: Vasella, A.]]
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[[Category: Vasella A]]
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[[Category: Xie, J.]]
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[[Category: Xie J]]
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[[Category: Apramycin]]
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[[Category: Ribosome]]
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[[Category: Toxicity]]
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Current revision

Structure of ribosome-apramycin complexes

PDB ID 4aqy

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