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4a1u
From Proteopedia
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==Crystal structure of alpha-beta-foldamer 2c in complex with Bcl-xL== | ==Crystal structure of alpha-beta-foldamer 2c in complex with Bcl-xL== | ||
| - | <StructureSection load='4a1u' size='340' side='right' caption='[[4a1u]], [[Resolution|resolution]] 1.54Å' scene=''> | + | <StructureSection load='4a1u' size='340' side='right'caption='[[4a1u]], [[Resolution|resolution]] 1.54Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4a1u]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4a1u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A1U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A1U FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.54Å</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=B3A:(3S)-3-AMINOBUTANOIC+ACID'>B3A</scene>, <scene name='pdbligand=B3E:(3S)-3-AMINOHEXANEDIOIC+ACID'>B3E</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HR7:(3S)-3-AMINO-6-[(DIAMINOMETHYLIDENE)AMINO]HEXANOIC+ACID'>HR7</scene>, <scene name='pdbligand=HT7:(3S)-3-AMINO-4-(1H-INDOL-3-YL)BUTANOIC+ACID'>HT7</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a1u OCA], [https://pdbe.org/4a1u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a1u RCSB], [https://www.ebi.ac.uk/pdbsum/4a1u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a1u ProSAT]</span></td></tr> | |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </table> |
| - | <table> | + | == Function == |
| + | [https://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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Evaluation of Diverse alpha/beta-Backbone Patterns for Functional alpha-Helix Mimicry: Analogues of the Bim BH3 Domain.,Boersma MD, Haase HS, Peterson-Kaufman KJ, Lee EF, Clarke OB, Colman PM, Smith BJ, Horne WS, Fairlie WD, Gellman SH J Am Chem Soc. 2011 Dec 8. PMID:22040025<ref>PMID:22040025</ref> | Evaluation of Diverse alpha/beta-Backbone Patterns for Functional alpha-Helix Mimicry: Analogues of the Bim BH3 Domain.,Boersma MD, Haase HS, Peterson-Kaufman KJ, Lee EF, Clarke OB, Colman PM, Smith BJ, Horne WS, Fairlie WD, Gellman SH J Am Chem Soc. 2011 Dec 8. PMID:22040025<ref>PMID:22040025</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
| + | <div class="pdbe-citations 4a1u" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Synthetic construct]] |
| - | [[Category: | + | [[Category: Boersma MD]] |
| - | [[Category: | + | [[Category: Clarke OB]] |
| - | [[Category: | + | [[Category: Colman PM]] |
| - | [[Category: | + | [[Category: Fairlie WD]] |
| - | [[Category: | + | [[Category: Gellman SH]] |
| - | [[Category: | + | [[Category: Haase HS]] |
| - | [[Category: | + | [[Category: Horne WS]] |
| - | [[Category: | + | [[Category: Kaufman KJ]] |
| - | [[Category: | + | [[Category: Lee EF]] |
| - | [[Category: | + | [[Category: Smith BJ]] |
| - | + | ||
| - | + | ||
Current revision
Crystal structure of alpha-beta-foldamer 2c in complex with Bcl-xL
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Categories: Homo sapiens | Large Structures | Synthetic construct | Boersma MD | Clarke OB | Colman PM | Fairlie WD | Gellman SH | Haase HS | Horne WS | Kaufman KJ | Lee EF | Smith BJ
