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3vgj

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==Crystal of Plasmodium falciparum tyrosyl-tRNA synthetase (PfTyrRS)in complex with adenylate analog==
==Crystal of Plasmodium falciparum tyrosyl-tRNA synthetase (PfTyrRS)in complex with adenylate analog==
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<StructureSection load='3vgj' size='340' side='right' caption='[[3vgj]], [[Resolution|resolution]] 2.21&Aring;' scene=''>
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<StructureSection load='3vgj' size='340' side='right'caption='[[3vgj]], [[Resolution|resolution]] 2.21&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3vgj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VGJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VGJ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3vgj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VGJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VGJ FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=YAP:5-O-[(R)-{[(2S)-2-AMINO-3-(4-HYDROXYPHENYL)PROPANOYL]OXY}(HYDROXY)PHOSPHORYL]ADENOSINE'>YAP</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.212&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1q11|1q11]], [[1n3l|1n3l]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=TYR:TYROSINE'>TYR</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MAL8P1.125 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 Plasmodium falciparum])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vgj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vgj OCA], [https://pdbe.org/3vgj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vgj RCSB], [https://www.ebi.ac.uk/pdbsum/3vgj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vgj ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tyrosine--tRNA_ligase Tyrosine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.1 6.1.1.1] </span></td></tr>
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</table>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vgj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vgj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3vgj RCSB], [http://www.ebi.ac.uk/pdbsum/3vgj PDBsum]</span></td></tr>
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== Function ==
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<table>
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[https://www.uniprot.org/uniprot/Q8IAR7_PLAF7 Q8IAR7_PLAF7]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Malaria infection triggers pro-inflammatory responses in humans that are detrimental to host health. Parasite-induced enhancement in cytokine levels correlate with malaria-associated pathologies. Here we show that parasite tyrosyl-tRNA synthetase (PfTyrRS), a housekeeping protein translation enzyme, induces pro-inflammatory responses from host immune cells. PfTyrRS exits from the parasite cytoplasm into the infected red blood cell (iRBC) cytoplasm, from where it is released into the extracellular medium on iRBC lysis. Using its ELR peptide motif, PfTyrRS specifically binds to and internalizes into host macrophages, leading to enhanced secretion of the pro-inflammatory cytokines TNF-alpha and IL-6. PfTyrRS-macrophage interaction also augments expression of adherence-linked host endothelial receptors ICAM-1 and VCAM-1. Our description of PfTyrRS as a parasite-secreted protein that triggers pro-inflammatory host responses, along with its atomic resolution crystal structure in complex with tyrosyl-adenylate, provides a novel platform for targeting PfTyrRS in anti-parasitic strategies.
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Malaria parasite tyrosyl-tRNA synthetase secretion triggers pro-inflammatory responses.,Bhatt TK, Khan S, Dwivedi VP, Banday MM, Sharma A, Chandele A, Camacho N, de Pouplana LR, Wu Y, Craig AG, Mikkonen AT, Maier AG, Yogavel M, Sharma A Nat Commun. 2011 Nov 8;2:530. doi: 10.1038/ncomms1522. PMID:22068597<ref>PMID:22068597</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Plasmodium falciparum]]
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[[Category: Large Structures]]
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[[Category: Tyrosine--tRNA ligase]]
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[[Category: Plasmodium falciparum 3D7]]
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[[Category: Banday, M M.]]
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[[Category: Banday MM]]
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[[Category: Bhatt, T K.]]
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[[Category: Bhatt TK]]
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[[Category: Khan, S.]]
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[[Category: Khan S]]
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[[Category: Sharma, A.]]
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[[Category: Sharma A]]
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[[Category: Yogavel, M.]]
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[[Category: Yogavel M]]
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[[Category: Ligase]]
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[[Category: Synthetase]]
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[[Category: Tyrr]]
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Current revision

Crystal of Plasmodium falciparum tyrosyl-tRNA synthetase (PfTyrRS)in complex with adenylate analog

PDB ID 3vgj

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