4a32

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==CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A PYRAZOLE SULPHONAMIDE LIGAND==
==CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A PYRAZOLE SULPHONAMIDE LIGAND==
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<StructureSection load='4a32' size='340' side='right' caption='[[4a32]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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<StructureSection load='4a32' size='340' side='right'caption='[[4a32]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4a32]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A32 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A32 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4a32]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A32 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A32 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2CD:3,5-DICHLORO-3-[(DIETHYLAMINO)METHYL]-N-(1,3,5-TRIMETHYL-1H-PYRAZOL-4-YL)BIPHENYL-4-SULFONAMIDE'>2CD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4a33|4a33]], [[4a30|4a30]], [[2wsa|2wsa]], [[4a2z|4a2z]], [[4a31|4a31]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2CD:3,5-DICHLORO-3-[(DIETHYLAMINO)METHYL]-N-(1,3,5-TRIMETHYL-1H-PYRAZOL-4-YL)BIPHENYL-4-SULFONAMIDE'>2CD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene></td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a32 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a32 OCA], [https://pdbe.org/4a32 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a32 RCSB], [https://www.ebi.ac.uk/pdbsum/4a32 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a32 ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a32 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a32 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a32 RCSB], [http://www.ebi.ac.uk/pdbsum/4a32 PDBsum]</span></td></tr>
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</table>
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<table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q4Q5S8_LEIMA Q4Q5S8_LEIMA] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Discovery of a novel class of orally active trypanocidal N-myristoyltransferase inhibitors.,Brand S, Cleghorn LA, McElroy SP, Robinson DA, Smith VC, Hallyburton I, Harrison JR, Norcross NR, Spinks D, Bayliss T, Norval S, Stojanovski L, Torrie LS, Frearson JA, Brenk R, Fairlamb AH, Ferguson MA, Read KD, Wyatt PG, Gilbert IH J Med Chem. 2012 Jan 12;55(1):140-52. Epub 2011 Dec 7. PMID:22148754<ref>PMID:22148754</ref>
Discovery of a novel class of orally active trypanocidal N-myristoyltransferase inhibitors.,Brand S, Cleghorn LA, McElroy SP, Robinson DA, Smith VC, Hallyburton I, Harrison JR, Norcross NR, Spinks D, Bayliss T, Norval S, Stojanovski L, Torrie LS, Frearson JA, Brenk R, Fairlamb AH, Ferguson MA, Read KD, Wyatt PG, Gilbert IH J Med Chem. 2012 Jan 12;55(1):140-52. Epub 2011 Dec 7. PMID:22148754<ref>PMID:22148754</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4a32" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Glycylpeptide N-tetradecanoyltransferase]]
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[[Category: Large Structures]]
[[Category: Leishmania major]]
[[Category: Leishmania major]]
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[[Category: Brand, S.]]
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[[Category: Brand S]]
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[[Category: Brenk, R.]]
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[[Category: Brenk R]]
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[[Category: Cleghorn, L A.T.]]
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[[Category: Cleghorn LAT]]
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[[Category: Fairlamb, A H.]]
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[[Category: Fairlamb AH]]
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[[Category: Ferguson, M A.J.]]
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[[Category: Ferguson MAJ]]
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[[Category: Frearson, J A.]]
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[[Category: Frearson JA]]
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[[Category: Gilbert, I H.]]
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[[Category: Gilbert IH]]
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[[Category: Hallyburton, I.]]
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[[Category: Hallyburton I]]
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[[Category: Harrison, J R.]]
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[[Category: Harrison JR]]
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[[Category: Mcelroy, S P.]]
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[[Category: McElroy SP]]
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[[Category: Norcross, N R.]]
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[[Category: Norcross NR]]
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[[Category: Norval, S.]]
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[[Category: Norval S]]
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[[Category: Read, K D.]]
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[[Category: Read KD]]
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[[Category: Robinson, D A.]]
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[[Category: Robinson DA]]
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[[Category: Smith, V C.]]
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[[Category: Smith VC]]
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[[Category: Spinks, D.]]
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[[Category: Spinks D]]
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[[Category: Stojanovski, L.]]
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[[Category: Stojanovski L]]
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[[Category: Torrie, L S.]]
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[[Category: Torrie LS]]
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[[Category: Wyatt, P G.]]
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[[Category: Wyatt PG]]
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[[Category: Acyltransferase]]
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[[Category: Drug discovery]]
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[[Category: Leishmaniasis]]
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[[Category: Transferase]]
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Current revision

CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A PYRAZOLE SULPHONAMIDE LIGAND

PDB ID 4a32

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