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4aei

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==Crystal structure of the AaHII-Fab4C1 complex==
==Crystal structure of the AaHII-Fab4C1 complex==
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<StructureSection load='4aei' size='340' side='right' caption='[[4aei]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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<StructureSection load='4aei' size='340' side='right'caption='[[4aei]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4aei]] is a 9 chain structure with sequence from [http://en.wikipedia.org/wiki/Androctonus_australis_hector Androctonus australis hector] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AEI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AEI FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4aei]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Androctonus_australis_hector Androctonus australis hector] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AEI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AEI FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1seg|1seg]], [[1ptx|1ptx]], [[1aho|1aho]], [[4aeh|4aeh]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4aei FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aei OCA], [https://pdbe.org/4aei PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4aei RCSB], [https://www.ebi.ac.uk/pdbsum/4aei PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4aei ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4aei FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aei OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4aei RCSB], [http://www.ebi.ac.uk/pdbsum/4aei PDBsum]</span></td></tr>
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</table>
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<table>
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== Function ==
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[https://www.uniprot.org/uniprot/SCX2_ANDAU SCX2_ANDAU] Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. This toxin is active against mammals.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4aei" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Monoclonal Antibody|Monoclonal Antibody]]
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*[[Hemolysin 3D structures|Hemolysin 3D structures]]
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*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Androctonus australis hector]]
[[Category: Androctonus australis hector]]
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Bourne, Y.]]
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[[Category: Bourne Y]]
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[[Category: Conrod, S.]]
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[[Category: Conrod S]]
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[[Category: Fabrichny, I P.]]
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[[Category: Fabrichny IP]]
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[[Category: Marchot, P.]]
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[[Category: Marchot P]]
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[[Category: Martin-Eauclaire, M F.]]
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[[Category: Martin-Eauclaire MF]]
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[[Category: Mondielli, G.]]
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[[Category: Mondielli G]]
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[[Category: Alpha-toxin]]
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[[Category: Combining site]]
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[[Category: Conformational rearrangement]]
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[[Category: Epitope]]
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[[Category: Immune system-toxin complex]]
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[[Category: Pharmacological site]]
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[[Category: Venom]]
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[[Category: Voltage-activated sodium channel]]
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Current revision

Crystal structure of the AaHII-Fab4C1 complex

PDB ID 4aei

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