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| - | ==Trypanosoma cruzi Glucose-6-P Dehydrogenase in complex with G6P==
| + | #REDIRECT [[6d24]] This PDB entry is obsolete and replaced by 6d24 |
| - | <StructureSection load='4em5' size='340' side='right' caption='[[4em5]], [[Resolution|resolution]] 3.35Å' scene=''>
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| - | == Structural highlights ==
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| - | <table><tr><td colspan='2'>[[4em5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EM5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EM5 FirstGlance]. <br>
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| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BG6:BETA-D-GLUCOSE-6-PHOSPHATE'>BG6</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
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| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4e9i|4e9i]], [[2bhl|2bhl]]</td></tr>
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| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">G6PDH1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5693 Trypanosoma cruzi])</td></tr>
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| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucose-6-phosphate_dehydrogenase Glucose-6-phosphate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.49 1.1.1.49] </span></td></tr>
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| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4em5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4em5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4em5 RCSB], [http://www.ebi.ac.uk/pdbsum/4em5 PDBsum]</span></td></tr>
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| - | <table>
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| - | <div style="background-color:#fffaf0;">
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| - | == Publication Abstract from PubMed ==
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| - | An N-terminally truncated version of the enzyme glucose-6-phosphate dehydrogenase from Trypanosoma cruzi lacking the first 37 residues was crystallized both in its apo form and in a binary complex with glucose 6-phosphate. The crystals both belonged to space group P2(1) and diffracted to 2.85 and 3.35 A resolution, respectively. Self-rotation function maps were consistent with point group 222. The structure was solved by molecular replacement, confirming a tetrameric quaternary structure.
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| - | Expression, crystallization and preliminary X-ray crystallographic analysis of glucose-6-phosphate dehydrogenase from the human pathogen Trypanosoma cruzi in complex with substrate.,Ortiz C, Larrieux N, Medeiros A, Botti H, Comini M, Buschiazzo A Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Nov 1;67(Pt 11):1457-61., Epub 2011 Oct 27. PMID:22102256<ref>PMID:22102256</ref>
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| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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| - | </div>
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| - | == References ==
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| - | <references/>
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| - | __TOC__
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| - | </StructureSection>
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| - | [[Category: Glucose-6-phosphate dehydrogenase]]
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| - | [[Category: Trypanosoma cruzi]]
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| - | [[Category: Botti, H.]]
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| - | [[Category: Buschiazzo, A.]]
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| - | [[Category: Comini, M A.]]
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| - | [[Category: Ortiz, C.]]
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| - | [[Category: Dehydrogenase]]
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| - | [[Category: Oxidoreductase]]
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| - | [[Category: Pentose phosphate pathway]]
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| - | [[Category: Regulatory enzyme]]
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