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1be3

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[[Image:1be3.gif|left|200px]]
 
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{{Structure
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==CYTOCHROME BC1 COMPLEX FROM BOVINE==
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|PDB= 1be3 |SIZE=350|CAPTION= <scene name='initialview01'>1be3</scene>, resolution 3.0&Aring;
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<StructureSection load='1be3' size='340' side='right'caption='[[1be3]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=HEC:HEME+C'>HEC</scene> and <scene name='pdbligand=FES:FE2/S2 (INORGANIC) CLUSTER'>FES</scene>
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<table><tr><td colspan='2'>[[1be3]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BE3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BE3 FirstGlance]. <br>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Ubiquinol--cytochrome-c_reductase Ubiquinol--cytochrome-c reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.2.2 1.10.2.2]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=HEC:HEME+C'>HEC</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1be3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1be3 OCA], [https://pdbe.org/1be3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1be3 RCSB], [https://www.ebi.ac.uk/pdbsum/1be3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1be3 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/QCR1_BOVIN QCR1_BOVIN] This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/be/1be3_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1be3 ConSurf].
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<div style="clear:both"></div>
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'''CYTOCHROME BC1 COMPLEX FROM BOVINE'''
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==See Also==
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*[[Cytochrome C 3D structures|Cytochrome C 3D structures]]
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*[[Cytochrome bc1 3D structures|Cytochrome bc1 3D structures]]
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==Overview==
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__TOC__
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Mitochondrial cytochrome bc1 complex performs two functions: It is a respiratory multienzyme complex and it recognizes a mitochondrial targeting presequence. Refined crystal structures of the 11-subunit bc1 complex from bovine heart reveal full views of this bifunctional enzyme. The "Rieske" iron-sulfur protein subunit shows significant conformational changes in different crystal forms, suggesting a new electron transport mechanism of the enzyme. The mitochondrial targeting presequence of the "Rieske" protein (subunit 9) is lodged between the two "core" subunits at the matrix side of the complex. These "core" subunits are related to the matrix processing peptidase, and the structure unveils how mitochondrial targeting presequences are recognized.
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</StructureSection>
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==About this Structure==
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1BE3 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BE3 OCA].
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==Reference==
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Complete structure of the 11-subunit bovine mitochondrial cytochrome bc1 complex., Iwata S, Lee JW, Okada K, Lee JK, Iwata M, Rasmussen B, Link TA, Ramaswamy S, Jap BK, Science. 1998 Jul 3;281(5373):64-71. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9651245 9651245]
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[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Ubiquinol--cytochrome-c reductase]]
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[[Category: Iwata M]]
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[[Category: Iwata, M.]]
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[[Category: Iwata S]]
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[[Category: Iwata, S.]]
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[[Category: Jap BK]]
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[[Category: Jap, B K.]]
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[[Category: Lee JK]]
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[[Category: Lee, J K.]]
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[[Category: Lee JW]]
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[[Category: Lee, J W.]]
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[[Category: Okada K]]
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[[Category: Okada, K.]]
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[[Category: Ramaswamy S]]
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[[Category: Ramaswamy, S.]]
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[[Category: FES]]
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[[Category: HEC]]
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[[Category: HEM]]
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[[Category: cytochrome]]
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[[Category: electron transport]]
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[[Category: membrane protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:09:46 2008''
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Current revision

CYTOCHROME BC1 COMPLEX FROM BOVINE

PDB ID 1be3

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