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4e5w
From Proteopedia
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==JAK1 kinase (JH1 domain) in complex with compound 26== | ==JAK1 kinase (JH1 domain) in complex with compound 26== | ||
| - | <StructureSection load='4e5w' size='340' side='right' caption='[[4e5w]], [[Resolution|resolution]] 1.86Å' scene=''> | + | <StructureSection load='4e5w' size='340' side='right'caption='[[4e5w]], [[Resolution|resolution]] 1.86Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4e5w]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4e5w]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E5W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4E5W FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0NT:[4-(IMIDAZO[4,5-D]PYRROLO[2,3-B]PYRIDIN-1(6H)-YL)PIPERIDIN-1-YL][(2S)-1-(PROPAN-2-YL)PYRROLIDIN-2-YL]METHANONE'>0NT</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0NT:[4-(IMIDAZO[4,5-D]PYRROLO[2,3-B]PYRIDIN-1(6H)-YL)PIPERIDIN-1-YL][(2S)-1-(PROPAN-2-YL)PYRROLIDIN-2-YL]METHANONE'>0NT</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4e5w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e5w OCA], [https://pdbe.org/4e5w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4e5w RCSB], [https://www.ebi.ac.uk/pdbsum/4e5w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4e5w ProSAT]</span></td></tr> | |
| - | <tr | + | </table> |
| - | + | == Function == | |
| - | + | [[https://www.uniprot.org/uniprot/JAK1_HUMAN JAK1_HUMAN]] Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor. | |
| - | + | ||
| - | <table> | + | |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 4e5w" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Janus kinase|Janus kinase]] | + | *[[Janus kinase 3D structures|Janus kinase 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Murray | + | [[Category: Murray JM]] |
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Current revision
JAK1 kinase (JH1 domain) in complex with compound 26
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