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4di5
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==Co-crystal structure of WT 5-epi-Aristolochene synthase from Nicotiana tobaccum with geraniline== | ==Co-crystal structure of WT 5-epi-Aristolochene synthase from Nicotiana tobaccum with geraniline== | ||
| - | <StructureSection load='4di5' size='340' side='right' caption='[[4di5]], [[Resolution|resolution]] 2.30Å' scene=''> | + | <StructureSection load='4di5' size='340' side='right'caption='[[4di5]], [[Resolution|resolution]] 2.30Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4di5]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4di5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Nicotiana_tabacum Nicotiana tabacum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DI5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DI5 FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1GA:GERANILINE'>1GA</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=DPO:DIPHOSPHATE'>DPO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1GA:GERANILINE'>1GA</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=DPO:DIPHOSPHATE'>DPO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |
| - | <tr | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4di5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4di5 OCA], [https://pdbe.org/4di5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4di5 RCSB], [https://www.ebi.ac.uk/pdbsum/4di5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4di5 ProSAT]</span></td></tr> |
| - | + | </table> | |
| - | <table> | + | == Function == |
| + | [https://www.uniprot.org/uniprot/5EAS_TOBAC 5EAS_TOBAC] Catalyzes the cyclization of trans,trans-farnesyl diphosphate (FPP) to the bicyclic intermediate 5-epi-aristolochene, initial step in the conversion of FPP to the sesquiterpenoid antifungal phytoalexin capsidiol. Produces germacrene A as an enzyme-bound intermediate that is not released by the enzyme, but is further cyclized to produce the bicyclic 5-epi-aristolochene. | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Large Structures]] |
[[Category: Nicotiana tabacum]] | [[Category: Nicotiana tabacum]] | ||
| - | [[Category: Crenshaw | + | [[Category: Crenshaw CM]] |
| - | [[Category: Noel | + | [[Category: Noel JP]] |
| - | [[Category: Starks | + | [[Category: Starks C]] |
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Current revision
Co-crystal structure of WT 5-epi-Aristolochene synthase from Nicotiana tobaccum with geraniline
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