1fms

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==Structure of complex between cyclohexyl-bis-furamidine and d(CGCGAATTCGCG)==
==Structure of complex between cyclohexyl-bis-furamidine and d(CGCGAATTCGCG)==
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<StructureSection load='1fms' size='340' side='right' caption='[[1fms]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<StructureSection load='1fms' size='340' side='right'caption='[[1fms]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1fms]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FMS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FMS FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1fms]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FMS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FMS FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=D35:2,5-BIS{[4-(N-CYCLOHEXYLDIAMINOMETHYL)PHENYL]}FURAN'>D35</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fms FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fms OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1fms RCSB], [http://www.ebi.ac.uk/pdbsum/1fms PDBsum]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D35:2,5-BIS{[4-(N-CYCLOHEXYLDIAMINOMETHYL)PHENYL]}FURAN'>D35</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<table>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fms FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fms OCA], [https://pdbe.org/1fms PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fms RCSB], [https://www.ebi.ac.uk/pdbsum/1fms PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fms ProSAT]</span></td></tr>
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<div style="background-color:#fffaf0;">
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</table>
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== Publication Abstract from PubMed ==
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2,5-Bis-[4-(N-cyclobutyl-amidino)phenyl] furan and 2,5-bis-[4-(N-cyclohexyl-amidino)phenyl] furan have activity against Pneumocystis carinii and also show cytotoxicity against several tumour cell lines. These activities are correlated with DNA-binding abilities; the crystal structures of complexes with the DNA sequence d(CGCGAATTCGCG) is reported here. Interactions with, and effects on, the DNA minor groove, are found to be factors in the biological properties of these compounds.
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DNA minor groove interactions and the biological activity of 2,5-bis.,Simpson IJ, Lee M, Kumar A, Boykin DW, Neidle S Bioorg Med Chem Lett. 2000 Dec 4;10(23):2593-7. PMID:11128631<ref>PMID:11128631</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Boykin, D W.]]
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[[Category: Large Structures]]
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[[Category: Kumar, A.]]
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[[Category: Boykin DW]]
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[[Category: Lee, M.]]
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[[Category: Kumar A]]
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[[Category: Neidle, S.]]
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[[Category: Lee M]]
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[[Category: Simpson, I J.]]
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[[Category: Neidle S]]
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[[Category: Dna]]
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[[Category: Simpson IJ]]
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[[Category: Dna-drug minor groove complex]]
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Current revision

Structure of complex between cyclohexyl-bis-furamidine and d(CGCGAATTCGCG)

PDB ID 1fms

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