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1kxk

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==Crystal Structure of a RNA Molecule Containing Domain 5 and 6 of the Yeast ai5g Group II Self-splicing Intron==
==Crystal Structure of a RNA Molecule Containing Domain 5 and 6 of the Yeast ai5g Group II Self-splicing Intron==
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<StructureSection load='1kxk' size='340' side='right' caption='[[1kxk]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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<StructureSection load='1kxk' size='340' side='right'caption='[[1kxk]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1kxk]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KXK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KXK FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1kxk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KXK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KXK FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kxk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kxk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1kxk RCSB], [http://www.ebi.ac.uk/pdbsum/1kxk PDBsum]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<table>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kxk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kxk OCA], [https://pdbe.org/1kxk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kxk RCSB], [https://www.ebi.ac.uk/pdbsum/1kxk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kxk ProSAT]</span></td></tr>
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<div style="background-color:#fffaf0;">
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</table>
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== Publication Abstract from PubMed ==
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Group II self-splicing introns catalyze autoexcision from precursor RNA transcripts by a mechanism strikingly similar to that of the spliceosome, an RNA-protein assembly responsible for splicing together the protein-coding parts of most eukaryotic pre-mRNAs. Splicing in both cases initiates via nucleophilic attack at the 5' splice site by the 2' OH of a conserved intron adenosine residue, creating a branched (lariat) intermediate. Here, we describe the crystal structure at 3.0 A resolution of a 70-nucleotide RNA containing the catalytically essential domains 5 and 6 of the yeast ai5gamma group II self-splicing intron, revealing an unexpected two-nucleotide bulged structure around the branch-point adenosine in domain 6.
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Structural insights into group II intron catalysis and branch-site selection.,Zhang L, Doudna JA Science. 2002 Mar 15;295(5562):2084-8. Epub 2002 Feb 21. PMID:11859154<ref>PMID:11859154</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Doudna, J A.]]
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[[Category: Large Structures]]
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[[Category: Zhang, L.]]
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[[Category: Saccharomyces cerevisiae]]
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[[Category: Double helix]]
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[[Category: Doudna JA]]
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[[Category: Rna]]
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[[Category: Zhang L]]
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[[Category: Tetraloop]]
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[[Category: Tetraloop receptor]]
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[[Category: Two-nucleotide bulge]]
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Current revision

Crystal Structure of a RNA Molecule Containing Domain 5 and 6 of the Yeast ai5g Group II Self-splicing Intron

PDB ID 1kxk

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