190d

<StructureSection load='190d' size='340' side='right' caption='[[190d]], [[Resolution|resolution]] 1.80&Aring;' scene=''>

<table><tr><td colspan='2'>[[190d]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=190D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=190D FirstGlance]. <br>

</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=190d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=190d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=190d RCSB], [http://www.ebi.ac.uk/pdbsum/190d PDBsum]</span></td></tr>

The crystal structure of d(C4) solved at 2.3-A resolution reveals a four-stranded molecule composed of two interdigitated or intercalated duplexes. The duplexes are held together by hemiprotonated cytosine-cytosine base pairs and are parallel stranded, but the two duplexes point in opposite directions. The molecule has a slow right-handed twist of 12.4 degrees between covalently linked cytosine base pairs, and the base stacking distance is 3.1 A. This is in general agreement with the NMR studies. A biological role for DNA in this conformation is suggested.

 

Crystal structure of a four-stranded intercalated DNA: d(C4).,Chen L, Cai L, Zhang X, Rich A Biochemistry. 1994 Nov 22;33(46):13540-6. PMID:7947764<ref>PMID:7947764</ref>

 

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<references/>

[[Category: Cai, L.]]

[[Category: Chen, L.]]

[[Category: Rich, A.]]

[[Category: Zhang, X.]]

[[Category: U-dna]]