1fmq

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==Cyclo-butyl-bis-furamidine complexed with dCGCGAATTCGCG==
==Cyclo-butyl-bis-furamidine complexed with dCGCGAATTCGCG==
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<StructureSection load='1fmq' size='340' side='right' caption='[[1fmq]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='1fmq' size='340' side='right'caption='[[1fmq]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1fmq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FMQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FMQ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1fmq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FMQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FMQ FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=D34:2,5-BIS{[4-(N-CYCLOBUTYLDIAMINOMETHYL)PHENYL]}FURAN'>D34</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fmq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fmq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1fmq RCSB], [http://www.ebi.ac.uk/pdbsum/1fmq PDBsum]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D34:2,5-BIS{[4-(N-CYCLOBUTYLDIAMINOMETHYL)PHENYL]}FURAN'>D34</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<table>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fmq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fmq OCA], [https://pdbe.org/1fmq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fmq RCSB], [https://www.ebi.ac.uk/pdbsum/1fmq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fmq ProSAT]</span></td></tr>
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<div style="background-color:#fffaf0;">
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</table>
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== Publication Abstract from PubMed ==
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2,5-Bis-[4-(N-cyclobutyl-amidino)phenyl] furan and 2,5-bis-[4-(N-cyclohexyl-amidino)phenyl] furan have activity against Pneumocystis carinii and also show cytotoxicity against several tumour cell lines. These activities are correlated with DNA-binding abilities; the crystal structures of complexes with the DNA sequence d(CGCGAATTCGCG) is reported here. Interactions with, and effects on, the DNA minor groove, are found to be factors in the biological properties of these compounds.
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DNA minor groove interactions and the biological activity of 2,5-bis.,Simpson IJ, Lee M, Kumar A, Boykin DW, Neidle S Bioorg Med Chem Lett. 2000 Dec 4;10(23):2593-7. PMID:11128631<ref>PMID:11128631</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Boykin, D W.]]
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[[Category: Large Structures]]
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[[Category: Kumar, A.]]
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[[Category: Boykin DW]]
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[[Category: Lee, M.]]
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[[Category: Kumar A]]
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[[Category: Neidle, S.]]
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[[Category: Lee M]]
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[[Category: Simpson, I J.]]
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[[Category: Neidle S]]
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[[Category: Dna]]
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[[Category: Simpson IJ]]
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[[Category: Dna-drug minor groove complex]]
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Current revision

Cyclo-butyl-bis-furamidine complexed with dCGCGAATTCGCG

PDB ID 1fmq

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