This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Urease accessory protein
From Proteopedia
(Difference between revisions)
(New page: <StructureSection load='3tj8' size='340' side='right' caption='Structure of UreE with Ni ion (PDB code 3tj8' scene=''> == Function == '''Urease accessory protein''' (Ure) is a Ni-co...) |
|||
| (16 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | + | <StructureSection load='3tj8' size='350' side='right' caption='Structure of UreE complex with formate and Ni+2 (PDB code [[3tj8]])' scene='59/590652/Cv/1' pspeed='8'> | |
| - | <StructureSection load='3tj8' size=' | + | |
== Function == | == Function == | ||
| - | '''Urease accessory protein''' (Ure) is a Ni-containing urea hydrolase involved in nitrogen recycling from arginine, ureide and purines. Ure proteins are involved in urease activation by the transfer of Ni into the protein. | + | '''Urease accessory protein''' (Ure) is a Ni-containing urea hydrolase involved in nitrogen recycling from arginine, ureide and purines. Ure proteins are involved in urease activation by the transfer of Ni into the protein<ref>PMID:11289508</ref>. |
| - | + | *'''UreD''' - required for nickel incorporation <ref>PMID:12471450</ref>.<br /> | |
| - | + | *'''UreE''' - see [[Molecular Playground/UreE]].<br /> | |
| - | + | *'''UreF''' - modulates the activation process of urease by eliminating the binding of Ni irons to noncarbamylated protein<ref>PMID:8808930</ref>.<br /> | |
| + | *'''UreG''' - modulates the activation process of urease in plants <ref>PMID:28710280</ref>.<br /> | ||
| + | *'''UreH''' - forms in combination with UreF and UreG a pre-activation complex which activates urease<ref>PMID:22013070</ref>.<br /> | ||
| + | *'''UreI''' - probably facilitates nickel incorporation.<br /> | ||
== Structural highlights == | == Structural highlights == | ||
| + | The <scene name='59/590652/Cv/3'>Ni+2 ion coordinates ligands which include 3 His residues belonging to the two monomers, water molecule</scene><ref>PMID:22010876</ref>. Water molecule is shown as red sphere. | ||
==3D structures of urease accessory protein== | ==3D structures of urease accessory protein== | ||
| - | + | [[Urease accessory protein 3D structures]] | |
| - | '''UreE''' | ||
| - | |||
| - | [[1gmv]], [[1gmu]] – KaUreE residues 1-143 (mutant) – ''Klebsiella aerogenes''<br /> | ||
| - | [[1gmw]] – KaUreE residues 1-143 (mutant) + Cu <br /> | ||
| - | [[4l3k]] – UreE + Zn + Ni – ''Sporosarcina pasteurii''<br /> | ||
| - | [[3tj8]], [[3ny0]] – HpUreE + Ni – ''Helicobacter pylori''<br /> | ||
| - | [[3tj9]] – HpUreE + Zn<br /> | ||
| - | [[3nxz]] – HpUreE + Cu<br /> | ||
| - | [[3la0]] – HpUreE + metal<br /> | ||
| - | [[3tja]], [[3l9z]] – HpUreE <br /> | ||
| - | [[1ear]], [[1eb0]] – UreE (mutant) + Zn – ''Bacillus pasteurii''<br /> | ||
| - | |||
| - | '''UreF''' | ||
| - | |||
| - | [[2wgl]], [[3cxn]], [[3o1q]] – HpUreF <br /> | ||
| - | [[3sf5]] – HpUreF + HpUreH<br /> | ||
| - | [[4hi0]] – HpUreF + HpUreG + HpUreH<br /> | ||
| - | |||
| - | '''UreI''' | ||
| - | |||
| - | [[3ux4]] – HpUreI <br /> | ||
| - | |||
| - | |||
| - | |||
| - | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
| + | </StructureSection> | ||
[[Category: Topic Page]] | [[Category: Topic Page]] | ||
Current revision
| |||||||||||
