Urease accessory protein

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(New page: <StructureSection load='3tj8' size='340' side='right' caption='Structure of UreE with Ni ion (PDB code 3tj8' scene=''> == Function == '''Urease accessory protein''' (Ure) is a Ni-co...)
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<StructureSection load='3tj8' size='350' side='right' caption='Structure of UreE complex with formate and Ni+2 (PDB code [[3tj8]])' scene='59/590652/Cv/1' pspeed='8'>
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<StructureSection load='3tj8' size='340' side='right' caption='Structure of UreE with Ni ion (PDB code [[3tj8]]' scene=''>
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== Function ==
== Function ==
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'''Urease accessory protein''' (Ure) is a Ni-containing urea hydrolase involved in nitrogen recycling from arginine, ureide and purines. Ure proteins are involved in urease activation by the transfer of Ni into the protein.
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'''Urease accessory protein''' (Ure) is a Ni-containing urea hydrolase involved in nitrogen recycling from arginine, ureide and purines. Ure proteins are involved in urease activation by the transfer of Ni into the protein<ref>PMID:11289508</ref>.
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== Disease ==
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*'''UreD''' - required for nickel incorporation <ref>PMID:12471450</ref>.<br />
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*'''UreE''' - see [[Molecular Playground/UreE]].<br />
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== Relevance ==
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*'''UreF''' - modulates the activation process of urease by eliminating the binding of Ni irons to noncarbamylated protein<ref>PMID:8808930</ref>.<br />
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*'''UreG''' - modulates the activation process of urease in plants <ref>PMID:28710280</ref>.<br />
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*'''UreH''' - forms in combination with UreF and UreG a pre-activation complex which activates urease<ref>PMID:22013070</ref>.<br />
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*'''UreI''' - probably facilitates nickel incorporation.<br />
== Structural highlights ==
== Structural highlights ==
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The <scene name='59/590652/Cv/3'>Ni+2 ion coordinates ligands which include 3 His residues belonging to the two monomers, water molecule</scene><ref>PMID:22010876</ref>. Water molecule is shown as red sphere.
==3D structures of urease accessory protein==
==3D structures of urease accessory protein==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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[[Urease accessory protein 3D structures]]
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'''UreE'''
 
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[[1gmv]], [[1gmu]] – KaUreE residues 1-143 (mutant) – ''Klebsiella aerogenes''<br />
 
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[[1gmw]] – KaUreE residues 1-143 (mutant) + Cu <br />
 
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[[4l3k]] – UreE + Zn + Ni – ''Sporosarcina pasteurii''<br />
 
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[[3tj8]], [[3ny0]] – HpUreE + Ni – ''Helicobacter pylori''<br />
 
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[[3tj9]] – HpUreE + Zn<br />
 
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[[3nxz]] – HpUreE + Cu<br />
 
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[[3la0]] – HpUreE + metal<br />
 
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[[3tja]], [[3l9z]] – HpUreE <br />
 
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[[1ear]], [[1eb0]] – UreE (mutant) + Zn – ''Bacillus pasteurii''<br />
 
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'''UreF'''
 
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[[2wgl]], [[3cxn]], [[3o1q]] – HpUreF <br />
 
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[[3sf5]] – HpUreF + HpUreH<br />
 
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[[4hi0]] – HpUreF + HpUreG + HpUreH<br />
 
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'''UreI'''
 
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[[3ux4]] – HpUreI <br />
 
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</StructureSection>
 
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
[[Category: Topic Page]]
[[Category: Topic Page]]

Current revision

Structure of UreE complex with formate and Ni+2 (PDB code 3tj8)

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Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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