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Sequestosome
From Proteopedia
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| - | <StructureSection load=' | + | <StructureSection load='2jy8' size='340' side='right' caption='Structure of human sequestosome UBA domain (PDB code [[2jy8]])' scene=''> |
== Function == | == Function == | ||
| + | '''Sequestosome''' (SQS) or '''p62''', is required for the formation and autophagic degredation of polyubiquitin-containg bodies. SQS may regulate signaling cascades through ubiquitination<ref>PMID:15340068</ref>. | ||
| - | + | == Structural highlights == | |
SQS is a multi-domain protein. SQS domain structure includes: <br /> | SQS is a multi-domain protein. SQS domain structure includes: <br /> | ||
| - | PB1 domain which contains Phox and Berm1<br /> | + | *PB1 domain which contains Phox and Berm1<br /> |
| - | ZZ-type zinc finger <br /> | + | *ZZ-type zinc finger <br /> |
| - | SMIR – SOD interaction domain<br /> | + | *SMIR – SOD interaction domain<br /> |
| - | TB – TRAF6 binding motif<br /> | + | *TB – TRAF6 binding motif<br /> |
| - | LC3 – microtubule-associated protein 1 light chain 3B<br /> | + | *LC3 – microtubule-associated protein 1 light chain 3B<br /> |
| - | LIR – interaction region<br /> | + | *LIR – interaction region<br /> |
| - | UBA – ubiquitin association domain. | + | *UBA – ubiquitin association domain. |
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== Relevance == | == Relevance == | ||
| - | + | SQS is associated with fibrillary tangles in Alzheimer disease<ref>PMID:22138392</ref>. | |
| - | + | ||
==3D structures of sequestosome== | ==3D structures of sequestosome== | ||
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | [[1q02]], [[2jy7]], [[2jy8]], [[2k0b]], [[2knv]] – | + | Domains: PB1 1-102; ZZ 120-180; UBA 387-436 |
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| + | [[1q02]], [[2jy7]], [[2jy8]], [[2k0b]], [[2knv]] – hSQS UBA domain – human - NMR<br /> | ||
| + | [[6jm4]] – hSQS-1 PB1 domain (mutant)<br /> | ||
| + | [[4uf8]], [[4uf9]], [[6tgy]], [[6th3]] – hSQS-1 PB1 domain – Cryo EM<br /> | ||
| + | [[5yp7]], [[5yp8]], [[5ypa]], [[5ypb]], [[5ypc]], [[5ype]], [[5ypg]], [[5yph]], [[5ypi]], [[6miu]] – hSQS-1 ZZ domain<br /> | ||
| + | [[6mj7]] – hSQS-1 ZZ domain + Arg<br /> | ||
| + | [[6khz]] – hSQS-1 ZZ domain + Gly<br /> | ||
| + | [[7r1o]] – hSQS-1 ZZ domain + drug<br /> | ||
| + | [[2ktr]] – rSQS PB1 domain – rat - NMR<br /> | ||
| + | [[2kkc]] – rSQS PB1 domain (mutant) - NMR<br /> | ||
| + | [[4mjs]] – hSQS-1 PB1 domain + protein kinase C zeta type<br /> | ||
[[3b0f]] – mSQS UBA domain – mouse <br /> | [[3b0f]] – mSQS UBA domain – mouse <br /> | ||
[[2rru]] – mSQS UBA domain - NMR<br /> | [[2rru]] – mSQS UBA domain - NMR<br /> | ||
| - | [[2ktr]] – rSQS PB1 domain – rat - NMR<br /> | ||
| - | [[2kkc]] – rSQS PB1 domain (mutant) - NMR<br /> | ||
| - | [[3ade]] – mSQS + KEAP-1 – mouse<br /> | ||
Current revision
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References
- ↑ Seibenhener ML, Babu JR, Geetha T, Wong HC, Krishna NR, Wooten MW. Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation. Mol Cell Biol. 2004 Sep;24(18):8055-68. PMID:15340068 doi:10.1128/MCB.24.18.8055-8068.2004
- ↑ Salminen A, Kaarniranta K, Haapasalo A, Hiltunen M, Soininen H, Alafuzoff I. Emerging role of p62/sequestosome-1 in the pathogenesis of Alzheimer's disease. Prog Neurobiol. 2012 Jan;96(1):87-95. doi: 10.1016/j.pneurobio.2011.11.005. Epub , 2011 Nov 22. PMID:22138392 doi:http://dx.doi.org/10.1016/j.pneurobio.2011.11.005
