1bjt

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:36, 7 February 2024) (edit) (undo)
 
(16 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1bjt.gif|left|200px]]
 
-
{{Structure
+
==TOPOISOMERASE II RESIDUES 409-1201==
-
|PDB= 1bjt |SIZE=350|CAPTION= <scene name='initialview01'>1bjt</scene>, resolution 2.5&Aring;
+
<StructureSection load='1bjt' size='340' side='right'caption='[[1bjt]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND=
+
<table><tr><td colspan='2'>[[1bjt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BJT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BJT FirstGlance]. <br>
-
|ACTIVITY= [http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3]
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
-
|GENE=
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bjt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bjt OCA], [https://pdbe.org/1bjt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bjt RCSB], [https://www.ebi.ac.uk/pdbsum/1bjt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bjt ProSAT]</span></td></tr>
-
}}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/TOP2_YEAST TOP2_YEAST] Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes.<ref>PMID:9685374</ref> <ref>PMID:23022727</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bj/1bjt_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bjt ConSurf].
 +
<div style="clear:both"></div>
-
'''TOPOISOMERASE II RESIDUES 409-1201'''
+
==See Also==
-
 
+
*[[Topoisomerase 3D structures|Topoisomerase 3D structures]]
-
 
+
== References ==
-
==Overview==
+
<references/>
-
Type II DNA topoisomerases mediate the passage of one DNA duplex through a transient break in another, an event essential for chromosome segregation and cell viability. The active sites of the type II topoisomerase dimer associate covalently with the DNA break-points and must separate by at least the width of the second DNA duplex to accommodate transport. A new structure of the Saccharomyces cerevisiae topoisomerase II DNA-binding and cleavage core suggests that in addition to conformational changes in the DNA-opening platform, a dramatic reorganization of accessory domains may occur during catalysis. These conformational differences have implications for both the DNA-breaking and duplex-transport events in the topo II reaction mechanism, suggest a mechanism by which two distinct drug-resistance loci interact, and illustrate the scope of structural changes in the cycling of molecular machines.
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
[[Category: Large Structures]]
-
1BJT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BJT OCA].
+
-
 
+
-
==Reference==
+
-
Quaternary changes in topoisomerase II may direct orthogonal movement of two DNA strands., Fass D, Bogden CE, Berger JM, Nat Struct Biol. 1999 Apr;6(4):322-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10201398 10201398]
+
-
[[Category: DNA topoisomerase (ATP-hydrolyzing)]]
+
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
-
[[Category: Single protein]]
+
[[Category: Berger JM]]
-
[[Category: Berger, J M.]]
+
[[Category: Bogden CE]]
-
[[Category: Bogden, C E.]]
+
[[Category: Fass D]]
-
[[Category: Fass, D.]]
+
-
[[Category: dna topology]]
+
-
[[Category: dna-binding]]
+
-
[[Category: quaternary change]]
+
-
[[Category: topoisomerase]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:11:59 2008''
+

Current revision

TOPOISOMERASE II RESIDUES 409-1201

PDB ID 1bjt

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1bjt"
Personal tools