4akd
From Proteopedia
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==High resolution structure of Mannose Binding lectin from Champedak (CMB)== | ==High resolution structure of Mannose Binding lectin from Champedak (CMB)== | ||
| - | <StructureSection load='4akd' size='340' side='right' caption='[[4akd]], [[Resolution|resolution]] 2.10Å' scene=''> | + | <StructureSection load='4akd' size='340' side='right'caption='[[4akd]], [[Resolution|resolution]] 2.10Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4akd]] is a 4 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4akd]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Artocarpus_integer Artocarpus integer]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AKD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AKD FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4akd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4akd OCA], [https://pdbe.org/4akd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4akd RCSB], [https://www.ebi.ac.uk/pdbsum/4akd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4akd ProSAT]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q7M1T4_ARTIN Q7M1T4_ARTIN] | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| - | + | Galactose-binding and mannose-binding lectins from the champedak fruit, which is native to South-east Asia, exhibit useful potential clinical applications. The specificity of the two lectins for their respective ligands allows the detection of potential cancer biomarkers and monitoring of the glycosylated state of proteins in human serum and/or urine. To fully understand and expand the use of these natural proteins, their complete sequences and crystal structures are presented here, together with details of sugar binding. | |
| - | + | Structures and binding specificity of galactose- and mannose-binding lectins from champedak: differences from jackfruit lectins.,Gabrielsen M, Abdul-Rahman PS, Othman S, Hashim OH, Cogdell RJ Acta Crystallogr F Struct Biol Commun. 2014 Jun;70(Pt 6):709-16. doi:, 10.1107/S2053230X14008966. Epub 2014 May 24. PMID:24915077<ref>PMID:24915077</ref> | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 4akd" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Mannose-binding protein|Mannose-binding protein]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Artocarpus integer]] | [[Category: Artocarpus integer]] | ||
| - | [[Category: Abdul-Rahman | + | [[Category: Large Structures]] |
| - | [[Category: Cogdell | + | [[Category: Abdul-Rahman PS]] |
| - | [[Category: Gabrielsen | + | [[Category: Cogdell RJ]] |
| - | [[Category: Hashim | + | [[Category: Gabrielsen M]] |
| - | [[Category: Othman | + | [[Category: Hashim OH]] |
| - | + | [[Category: Othman S]] | |
Current revision
High resolution structure of Mannose Binding lectin from Champedak (CMB)
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