1bo6

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[[Image:1bo6.gif|left|200px]]
 
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{{Structure
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==ESTROGEN SULFOTRANSFERASE WITH INACTIVE COFACTOR PAP AND VANADATE==
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|PDB= 1bo6 |SIZE=350|CAPTION= <scene name='initialview01'>1bo6</scene>, resolution 2.10&Aring;
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<StructureSection load='1bo6' size='340' side='right'caption='[[1bo6]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=VO4:VANADATE+ION'>VO4</scene> and <scene name='pdbligand=A3P:ADENOSINE-3'-5'-DIPHOSPHATE'>A3P</scene>
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<table><tr><td colspan='2'>[[1bo6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BO6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BO6 FirstGlance]. <br>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Estrone_sulfotransferase Estrone sulfotransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.8.2.4 2.8.2.4]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A3P:ADENOSINE-3-5-DIPHOSPHATE'>A3P</scene>, <scene name='pdbligand=VO4:VANADATE+ION'>VO4</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bo6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bo6 OCA], [https://pdbe.org/1bo6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bo6 RCSB], [https://www.ebi.ac.uk/pdbsum/1bo6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bo6 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ST1E1_MOUSE ST1E1_MOUSE] Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone. May play a role in the regulation of estrogen receptor activity by metabolizing free estradiol.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bo/1bo6_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bo6 ConSurf].
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<div style="clear:both"></div>
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'''ESTROGEN SULFOTRANSFERASE WITH INACTIVE COFACTOR PAP AND VANADATE'''
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==See Also==
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*[[Sulfotransferase 3D structures|Sulfotransferase 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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The structure of estrogen sulphotransferase has been solved in the presence of inactive cofactor PAP and substrate 17 beta-estradiol. This structure reveals structural similarities between cytosolic sulphotransferases and nucleotide kinases.
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[[Category: Large Structures]]
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==About this Structure==
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1BO6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BO6 OCA].
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==Reference==
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Crystal structure of estrogen sulphotransferase., Kakuta Y, Pedersen LG, Carter CW, Negishi M, Pedersen LC, Nat Struct Biol. 1997 Nov;4(11):904-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9360604 9360604]
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[[Category: Estrone sulfotransferase]]
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Single protein]]
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[[Category: Kakuta Y]]
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[[Category: Kakuta, Y.]]
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[[Category: Negishi M]]
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[[Category: Negishi, M.]]
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[[Category: Pedersen LC]]
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[[Category: Pedersen, L C.]]
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[[Category: A3P]]
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[[Category: VO4]]
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[[Category: pap]]
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[[Category: sulfonation]]
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[[Category: sulfotransferase]]
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[[Category: transferase]]
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[[Category: vanadate]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:13:36 2008''
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Current revision

ESTROGEN SULFOTRANSFERASE WITH INACTIVE COFACTOR PAP AND VANADATE

PDB ID 1bo6

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