4d0m

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==Phosphatidylinositol 4-kinase III beta in a complex with Rab11a-GTP- gamma-S and the Rab-binding domain of FIP3==
==Phosphatidylinositol 4-kinase III beta in a complex with Rab11a-GTP- gamma-S and the Rab-binding domain of FIP3==
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<StructureSection load='4d0m' size='340' side='right' caption='[[4d0m]], [[Resolution|resolution]] 6.00&Aring;' scene=''>
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<StructureSection load='4d0m' size='340' side='right'caption='[[4d0m]], [[Resolution|resolution]] 6.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4d0m]] is a 36 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D0M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D0M FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4d0m]] is a 36 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D0M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D0M FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=093:N-(5-(4-CHLORO-3-(2-HYDROXY-ETHYLSULFAMOYL)-+PHENYLTHIAZOLE-2-YL)-ACETAMIDE'>093</scene>, <scene name='pdbligand=GSP:5-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE'>GSP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 6&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1oiv|1oiv]], [[1oiw|1oiw]], [[1oix|1oix]], [[1yzk|1yzk]], [[2hv8|2hv8]], [[4c4p|4c4p]], [[4d0l|4d0l]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=093:N-(5-(4-CHLORO-3-(2-HYDROXY-ETHYLSULFAMOYL)-+PHENYLTHIAZOLE-2-YL)-ACETAMIDE'>093</scene>, <scene name='pdbligand=GSP:5-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE'>GSP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/1-phosphatidylinositol_4-kinase 1-phosphatidylinositol 4-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.67 2.7.1.67] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d0m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d0m OCA], [https://pdbe.org/4d0m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d0m RCSB], [https://www.ebi.ac.uk/pdbsum/4d0m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d0m ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d0m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d0m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4d0m RCSB], [http://www.ebi.ac.uk/pdbsum/4d0m PDBsum]</span></td></tr>
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</table>
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<table>
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== Function ==
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[https://www.uniprot.org/uniprot/PI4KB_HUMAN PI4KB_HUMAN] Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity).<ref>PMID:9405935</ref> <ref>PMID:10559940</ref> <ref>PMID:12749687</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4d0m" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Phosphatidylinositol 4-kinase|Phosphatidylinositol 4-kinase]]
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*[[Ras-related protein Rab 3D structures|Ras-related protein Rab 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: 1-phosphatidylinositol 4-kinase]]
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[[Category: Homo sapiens]]
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[[Category: Burke, J E.]]
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[[Category: Large Structures]]
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[[Category: Inglis, A J.]]
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[[Category: Burke JE]]
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[[Category: Masson, G R.]]
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[[Category: Inglis AJ]]
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[[Category: McLaughlin, S H.]]
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[[Category: Masson GR]]
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[[Category: Perisic, O.]]
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[[Category: McLaughlin SH]]
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[[Category: Rutaganira, F.]]
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[[Category: Perisic O]]
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[[Category: Shokat, K M.]]
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[[Category: Rutaganira F]]
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[[Category: Williams, R L.]]
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[[Category: Shokat KM]]
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[[Category: Family of rab interacting protein]]
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[[Category: Williams RL]]
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[[Category: Fip3]]
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[[Category: Golgi]]
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[[Category: Gtp]]
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[[Category: Lipid kinase]]
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[[Category: Phosphatidylinositol 4-kinase]]
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[[Category: Phosphoinositide]]
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[[Category: Pik93]]
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[[Category: Rab-binding domain]]
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[[Category: Rab11]]
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[[Category: Rbd]]
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[[Category: Recycling endosome]]
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[[Category: Signaling protein]]
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Current revision

Phosphatidylinositol 4-kinase III beta in a complex with Rab11a-GTP- gamma-S and the Rab-binding domain of FIP3

PDB ID 4d0m

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