4qi9
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of dihydrofolate reductase from Yersinia pestis complexed with methotrexate== | |
| + | <StructureSection load='4qi9' size='340' side='right'caption='[[4qi9]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4qi9]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Yersinia_pestis_CO92 Yersinia pestis CO92]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QI9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QI9 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.297Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=MTX:METHOTREXATE'>MTX</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qi9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qi9 OCA], [https://pdbe.org/4qi9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qi9 RCSB], [https://www.ebi.ac.uk/pdbsum/4qi9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qi9 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/A0A3N4BLI0_YERPE A0A3N4BLI0_YERPE] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.[ARBA:ARBA00025067][PIRNR:PIRNR000194] | ||
| - | + | ==See Also== | |
| - | + | *[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]] | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Yersinia pestis CO92]] | ||
| + | [[Category: Anderson WF]] | ||
| + | [[Category: Joachimiak A]] | ||
| + | [[Category: Kim Y]] | ||
| + | [[Category: Makowska-Grzyska M]] | ||
| + | [[Category: Maltseva N]] | ||
| + | [[Category: Mulligan R]] | ||
| + | [[Category: Shatsman S]] | ||
Current revision
Crystal structure of dihydrofolate reductase from Yersinia pestis complexed with methotrexate
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