4qj1
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4qj1 is ON HOLD Authors: Kim, Y., Makowska-Grzyska, M., Gu, M., Hedstrom, L., Anderson, W.F., Joachimiak, A., Center for Structural Genomics of Infe...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Co-crystal structure of the catalytic domain of the inosine monophosphate dehydrogenase from Cryptosporidium parvum with inhibitor N109== | |
| + | <StructureSection load='4qj1' size='340' side='right'caption='[[4qj1]], [[Resolution|resolution]] 2.42Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4qj1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Cryptosporidium_parvum Cryptosporidium parvum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QJ1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QJ1 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.415Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=N09:N-(4-CHLORO-3-METHOXYPHENYL)-2-(4-OXOCHROMENO[4,3-C]PYRAZOL-1(4H)-YL)ACETAMIDE'>N09</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qj1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qj1 OCA], [https://pdbe.org/4qj1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qj1 RCSB], [https://www.ebi.ac.uk/pdbsum/4qj1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qj1 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/IMDH_CRYPV IMDH_CRYPV] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity).<ref>PMID:15269207</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Inosine monophosphate dehydrogenase 3D structures|Inosine monophosphate dehydrogenase 3D structures]] | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Cryptosporidium parvum]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Anderson WF]] | ||
| + | [[Category: Gu M]] | ||
| + | [[Category: Hedstrom L]] | ||
| + | [[Category: Joachimiak A]] | ||
| + | [[Category: Kim Y]] | ||
| + | [[Category: Makowska-Grzyska M]] | ||
Current revision
Co-crystal structure of the catalytic domain of the inosine monophosphate dehydrogenase from Cryptosporidium parvum with inhibitor N109
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