This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4tlj
From Proteopedia
(Difference between revisions)
| (6 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Ultra-high resolution crystal structure of caprine Beta-lactoglobulin== | |
| + | <StructureSection load='4tlj' size='340' side='right'caption='[[4tlj]], [[Resolution|resolution]] 1.17Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4tlj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Capra_hircus Capra hircus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TLJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TLJ FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.17Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BU1:1,4-BUTANEDIOL'>BU1</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4tlj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tlj OCA], [https://pdbe.org/4tlj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4tlj RCSB], [https://www.ebi.ac.uk/pdbsum/4tlj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4tlj ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/LACB_CAPHI LACB_CAPHI] Primary component of whey, it binds retinol and is probably involved in the transport of that molecule. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | beta-Lactoglobulin (betalg) is the most abundant whey protein in the milks of ruminant animals. While bovine betalg has been subjected to a vast array of studies, little is known about the caprine ortholog. We present an ultra-high resolution crystal structure of caprine betalg complemented by analytical ultracentrifugation and small-angle X-ray scattering data. In both solution and crystalline states caprine betalg is dimeric (KD<5muM); however, our data suggest a flexible quaternary arrangement of subunits within the dimer. These structural findings will provide insight into relationships among structural, processing, nutritional and immunological characteristics that distinguish cow's and goat's milk. | ||
| - | + | Ultra-high resolution crystal structure of recombinant caprine beta-lactoglobulin.,Crowther JM, Lasse M, Suzuki H, Kessans SA, Loo TS, Norris GE, Hodgkinson AJ, Jameson GB, Dobson RC FEBS Lett. 2014 Sep 18. pii: S0014-5793(14)00685-1. doi:, 10.1016/j.febslet.2014.09.010. PMID:25241165<ref>PMID:25241165</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| + | </div> | ||
| + | <div class="pdbe-citations 4tlj" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Beta-lactoglobulin 3D structures|Beta-lactoglobulin 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Capra hircus]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Crowther JM]] | ||
| + | [[Category: Dobson RCJ]] | ||
| + | [[Category: Jameson GB]] | ||
| + | [[Category: Suzuki H]] | ||
Current revision
Ultra-high resolution crystal structure of caprine Beta-lactoglobulin
| |||||||||||
