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4czk

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==C. crescentus MreB, single filament, AMPPNP, MP265 inhibitor==
==C. crescentus MreB, single filament, AMPPNP, MP265 inhibitor==
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<StructureSection load='4czk' size='340' side='right' caption='[[4czk]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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<StructureSection load='4czk' size='340' side='right'caption='[[4czk]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4czk]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CZK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CZK FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4czk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Caulobacter_vibrioides Caulobacter vibrioides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CZK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CZK FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=F90:4-CHLOROBENZYL+CARBAMIMIDOTHIOATE'>F90</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.602&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cze|4cze]], [[4czf|4czf]], [[4czg|4czg]], [[4czh|4czh]], [[4czi|4czi]], [[4czj|4czj]], [[4czl|4czl]], [[4czm|4czm]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=F90:4-CHLOROBENZYL+CARBAMIMIDOTHIOATE'>F90</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4czk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4czk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4czk RCSB], [http://www.ebi.ac.uk/pdbsum/4czk PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4czk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4czk OCA], [https://pdbe.org/4czk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4czk RCSB], [https://www.ebi.ac.uk/pdbsum/4czk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4czk ProSAT]</span></td></tr>
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<table>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MREB_CAUVN MREB_CAUVN] Forms membrane-associated dynamic filaments that are essential for cell shape determination (PubMed:14982627, PubMed:17880425, PubMed:24843005). Acts by regulating cell wall synthesis and cell elongation, and thus cell shape (PubMed:14982627, PubMed:17880425). A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature (By similarity). Required for mid-cell peptidoglycan synthesis and cell division. Directs the localization of the cytosolic peptidoglycan precursor-synthesizing enzyme MurG (PubMed:17880425). Also required for proper chromosome segregation (PubMed:15707892). Directs the segregation of origin-proximal but not origin-distal loci (PubMed:15707892).[UniProtKB:P0A9X4]<ref>PMID:14982627</ref> <ref>PMID:15707892</ref> <ref>PMID:17880425</ref> <ref>PMID:24843005</ref> <ref>PMID:14982627</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4czk" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Ent, F van den.]]
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[[Category: Caulobacter vibrioides]]
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[[Category: Lowe, J.]]
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[[Category: Large Structures]]
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[[Category: Bacterial actin]]
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[[Category: Lowe J]]
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[[Category: Bacterial cytoskeleton]]
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[[Category: Van den Ent F]]
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[[Category: Structural protein]]
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Current revision

C. crescentus MreB, single filament, AMPPNP, MP265 inhibitor

PDB ID 4czk

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