3wuz

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==Crystal structure of the Ig V-set domain of human paired immunoglobulin-like type 2 receptor alpha==
==Crystal structure of the Ig V-set domain of human paired immunoglobulin-like type 2 receptor alpha==
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<StructureSection load='3wuz' size='340' side='right' caption='[[3wuz]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
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<StructureSection load='3wuz' size='340' side='right'caption='[[3wuz]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3wuz]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WUZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WUZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3wuz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WUZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WUZ FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3wv0|3wv0]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wuz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wuz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wuz RCSB], [http://www.ebi.ac.uk/pdbsum/3wuz PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wuz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wuz OCA], [https://pdbe.org/3wuz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wuz RCSB], [https://www.ebi.ac.uk/pdbsum/3wuz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wuz ProSAT]</span></td></tr>
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<table>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PILRA_HUMAN PILRA_HUMAN] Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRA is thought to act as a cellular signaling inhibitory receptor by recruiting cytoplasmic phosphatases like PTPN6/SHP-1 and PTPN11/SHP-2 via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. Receptor for PIANP.<ref>PMID:10903717</ref> <ref>PMID:18358807</ref> <ref>PMID:21241660</ref>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Arase, H.]]
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[[Category: Homo sapiens]]
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[[Category: Kajikawa, M.]]
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[[Category: Large Structures]]
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[[Category: Kogure, A.]]
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[[Category: Arase H]]
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[[Category: Kuroki, K.]]
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[[Category: Kajikawa M]]
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[[Category: Maenaka, K.]]
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[[Category: Kogure A]]
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[[Category: Maita, N.]]
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[[Category: Kuroki K]]
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[[Category: Nakamura, S.]]
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[[Category: Maenaka K]]
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[[Category: Ose, T.]]
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[[Category: Maita N]]
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[[Category: Satoh, T.]]
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[[Category: Nakamura S]]
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[[Category: Tabata, S.]]
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[[Category: Ose T]]
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[[Category: Wang, J.]]
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[[Category: Satoh T]]
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[[Category: Yamaguchi, M.]]
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[[Category: Tabata S]]
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[[Category: Immunoglobulin-like]]
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[[Category: Wang J]]
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[[Category: Immunological receptor]]
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[[Category: Yamaguchi M]]
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[[Category: Membrane]]
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[[Category: Membrane protein]]
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Current revision

Crystal structure of the Ig V-set domain of human paired immunoglobulin-like type 2 receptor alpha

PDB ID 3wuz

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