4ava

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==Crystal structure of protein lysine acetyltransferase Rv0998 from Mycobacterium tuberculosis==
==Crystal structure of protein lysine acetyltransferase Rv0998 from Mycobacterium tuberculosis==
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<StructureSection load='4ava' size='340' side='right' caption='[[4ava]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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<StructureSection load='4ava' size='340' side='right'caption='[[4ava]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4ava]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AVA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AVA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4ava]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AVA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AVA FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.698&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4avb|4avb]], [[4avc|4avc]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ava FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ava OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ava RCSB], [http://www.ebi.ac.uk/pdbsum/4ava PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ava FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ava OCA], [https://pdbe.org/4ava PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ava RCSB], [https://www.ebi.ac.uk/pdbsum/4ava PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ava ProSAT]</span></td></tr>
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<table>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PAT_MYCTU PAT_MYCTU] Catalyzes specifically the acetylation of the epsilon-amino group of a highly conserved lysine residue in acetyl-CoA synthetase (ACS). This acetylation results in the inactivation of ACS activity and could be important for mycobacteria to adjust to environmental changes.<ref>PMID:20507997</ref> <ref>PMID:21627103</ref> <ref>PMID:22773105</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4ava" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Large Structures]]
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[[Category: Alber, T.]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Fortune, S M.]]
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[[Category: Alber T]]
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[[Category: Lang, P T.]]
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[[Category: Fortune SM]]
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[[Category: Lee, H J.]]
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[[Category: Lang PT]]
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[[Category: Sassetti, C M.]]
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[[Category: Lee HJ]]
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[[Category: Allosteric regulation]]
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[[Category: Sassetti CM]]
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[[Category: Domain coupling]]
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[[Category: Transferase]]
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Current revision

Crystal structure of protein lysine acetyltransferase Rv0998 from Mycobacterium tuberculosis

PDB ID 4ava

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