Menin
From Proteopedia
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| - | <StructureSection load=' | + | <StructureSection load='3u86' size='450' side='right' caption='Structure of human menin (magenta) complex with Jun-D peptide (green) (PDB code [[3u86]]).' scene='59/591941/Cv/1'> |
== Function == | == Function == | ||
| - | '''Menin''' (Men) is a putative tumor suppressor. Men possesses two functional nuclear localization signals and inhibits transcriptional activation by JunD. | + | '''Menin''' or '''multiple endocrine neoplasia I''' (Men) is a putative tumor suppressor. Men possesses two functional nuclear localization signals and inhibits transcriptional activation by JunD<ref>PMID:11524225</ref>. |
== Disease == | == Disease == | ||
| - | + | Men mutations may be a common mechanism for inactivating tumor suppressor gene products in familial cancer<ref>PMID:15254225</ref>. | |
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== Structural highlights == | == Structural highlights == | ||
| + | <scene name='59/591941/Cv/3'>Jun-D interacts with Men in a deep pocket via 8 residues mainly</scene><ref>PMID:22327296</ref>. | ||
==3D structures of menin== | ==3D structures of menin== | ||
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | [[3u84]] – hMen – human<br /> | + | [[3u84]], [[7o9t]] – hMen – human<br /> |
| - | [[4og3]], [[4og4]], [[4og5]], [[4og6]], [[4og7]], [[4og8]] – hMen + inhibitor<br /> | + | [[4og3]], [[4og4]], [[4og5]], [[4og6]], [[4og7]], [[4og8]], [[6b41]], [[6bxh]], [[6bxy]], [[6by8]], [[6e1a]], [[6o5i]], [[6mnh]], [[6s2k]], [[6wnh]], [[7m4t]], [[7o9x]], [[7o9z]], [[7oa9]] – hMen + inhibitor<br /> |
| - | [[4gpq]], [[4gq3]], [[4gq4]] – hMen (mutant) + inhibitor<br /> | + | [[4gpq]], [[4gq3]], [[4gq4]], [[4x5y]], [[4x5z]], [[5db0]], [[5db1]], [[5db2]], [[5db3]], [[5dd9]], [[5dda]], [[5ddb]], [[5ddc]], [[5ddd]], [[5dde]], [[5ddf]], [[6pkc]], [[7uj4]], [[8e90]], [[8ig0]] – hMen (mutant) + inhibitor<br /> |
| - | [[4i80]] – hMen + peptide inhibitor<br /> | + | [[4i80]], [[6opj]] – hMen + peptide inhibitor<br /> |
[[3u85]] – hMen + histone-lysine N-methyltransferase Mll peptide<br /> | [[3u85]] – hMen + histone-lysine N-methyltransferase Mll peptide<br /> | ||
[[4gq6]] – hMen (mutant) + histone-lysine N-methyltransferase Mll peptide<br /> | [[4gq6]] – hMen (mutant) + histone-lysine N-methyltransferase Mll peptide<br /> | ||
[[3u86]] – hMen + JunD peptide<br /> | [[3u86]] – hMen + JunD peptide<br /> | ||
| - | [[ | + | [[3u88]] – hMen + histone-lysine N-methyltransferase Mll + lens epithelium-derived growth factor<br /> |
| - | + | [[8gpn]] – hMen in nucleosome – Cryo EM<br /> | |
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== References == | == References == | ||
Current revision
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