User:John S. de Banzie/Sandbox 2

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==RNA Stem and Loop Structure==
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==Zinc Finger==
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<StructureSection load='2qh2' size='400' side='right' caption='RNA hairpin loop from human telomerase RNA, [[2qh2]]' scene='59/590622/2qh2stick/3'>
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<StructureSection load='1mey' size='400' side='right' caption='Leucine Zipper, [[1mey]]' scene='59/590622/1meyspacefill/1'>
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Intramolecular hydrogen bonding in RNA molecules results in the formation of stem and loop structures (also known as hairpin loops).
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This zinc finger protein has one subunit. <scene name='59/590622/1meyspacefillunits/1'>Three zinc finger motifs</scene> fit into a major groove in the DNA. Each consists of an <scene name='59/590622/1meycartoon/1'>alpha helix, two short segments of beta pleated sheet, and a zinc ion (violet)</scene>.
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RNA in the stem of a stem and loop structure forms a double stranded <scene name='59/590622/2qh2stickends/1'>antiparallel</scene> right-handed helix with <scene name='59/590622/2qh2spacefill/1'>major and minor grooves</scene>. However this double helix is not the same as that of [[DNA]]. The most obvious difference is in the tilt of the bases, but there are also differences in the diameter and pitch of the helix<ref>Berg JM, Tymoczko JL, Stryer L. Biochemistry. 5th edition. New York: W H Freeman; 2002. Section 27.1, DNA Can Assume a Variety of Structural Forms. Available from: http://www.ncbi.nlm.nih.gov/books/NBK22585/</ref>.
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The RNA shown is 24 nucleotides long. Nucleotides 1 through 8 and 17 through 24 form the stem and nucleotides 9 through 16 form the loop. Note the <scene name='59/590622/2qh2bases/2'>complementary base pairing</scene> in the stem (A: red, C: green, G: orange, T: blue) and the unpaired bases in the loop (white).
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(The stem and loop structure shown is part of the RNA in human telomerase. Telomerase protects chromosomes by restoring DNA that is lost from the ends during DNA replication. The RNA is used as a template and the enzyme is thus an internally-templated RNA-dependant DNA polymerase<ref>Berg JM, Tymoczko JL, Stryer L. Biochemistry. 5th edition. New York: W H Freeman; 2002. Section 27.4, DNA Replication of Both Strands Proceeds Rapidly from Specific Start Sites. Available from: http://www.ncbi.nlm.nih.gov/books/NBK22587/</ref>.)
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</StructureSection>
</StructureSection>
== References ==
== References ==
<references/>
<references/>

Current revision

Zinc Finger

Leucine Zipper, 1mey

Drag the structure with the mouse to rotate

References

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John S. de Banzie

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