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Squalene synthase

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(New page: <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> == Function == '''Squalene synthase''' (SQS) catalyzes the conversion of 2 molecules...)
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<StructureSection load='3wca' size='350' side='right' caption='Structure of SQS complex with FPP analog and Mg+2 ions (green) (PDB code [[3wca]]).' scene='59/591996/Cv/1'>
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<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
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__TOC__
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== Function ==
== Function ==
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'''Squalene synthase''' (SQS) catalyzes the conversion of 2 molecules of farnesyl pyrophosphate (FPP) to the isoprenoid squalene. SQS is part of the isoprenoid biosynthesis pathway. SQS catalysis is the first step in the sterols synthesis including cholesterol.
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'''Squalene synthase''' (SQS) catalyzes the conversion of 2 molecules of farnesyl pyrophosphate (FPP) to the isoprenoid squalene. SQS is part of the isoprenoid biosynthesis pathway. SQS catalysis is the first step in the sterols synthesis including cholesterol<ref>PMID:11008488</ref>.
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*'''Dehydrosqualene synthase''' or '''phytene synthase''' catalyzes the condensation of farnesyl diphosphate producing presqualene diphosphate<ref>PMID:21098670</ref>.
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== Disease ==
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== Relevance ==
== Relevance ==
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SQS inhibitors are tested for antihyperlipidemic and antiatherosclerotic agents<ref>PMID:21864285</ref>.
== Structural highlights ==
== Structural highlights ==
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The <scene name='59/591996/Cv/6'>active site of SQS contains a substrate analog</scene><ref>PMID:24789335</ref>. Water molecules are shown as red spheres. <scene name='59/591996/Cv/7'>Mg coordination site</scene>.
==3D structures of squalene synthase==
==3D structures of squalene synthase==
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[[Squalene synthase 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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[[3vj8]], [[3vjb]] – hSQS – human<br />
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[[1ezf]] – hSQS (mutant) <br />
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'''SQS complexes'''
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[[3lee]] – hSQS + Mg + bisphosphonate inhibitor<br />
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[[3asx]], [[3q2z]], [[3q30]] – hSQS + Mg + PO4 + inhibitor<br />
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[[3vj9]], [[3vja]] – hSQS + Ni<br />
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[[3vjc]] – hSQS + Mg + PO4 + zaragozic acid<br />
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[[3v66]] – hSQS + PO4 + inhibitor<br />
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[[3wef]] – hSQS + FPP analog<br />
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[[3weg]] – hSQS + Mg + FPP analog<br />
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[[3weh]] – hSQS + Mg + presqualene pyrophosphate<br />
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[[3wei]] – hSQS (mutant) + Mn + presqualene pyrophosphate<br />
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[[3wej]], [[3wek]] – hSQS (mutant) + Mg + presqualene pyrophosphate<br />
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== References ==
== References ==
<references/>
<references/>
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</StructureSection>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Structure of SQS complex with FPP analog and Mg+2 ions (green) (PDB code 3wca).

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Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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