4qkv

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m (Protected "4qkv" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 4qkv is ON HOLD
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==Crystal structure of the mouse cavin1 HR1 domain==
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<StructureSection load='4qkv' size='340' side='right'caption='[[4qkv]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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Authors: Kovtun, O, Tillu, V, Parton, R. G. , Collins, B. M.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4qkv]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QKV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QKV FirstGlance]. <br>
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Description: Crystal structure of the mouse cavin1 HR1 domain
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qkv OCA], [https://pdbe.org/4qkv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qkv RCSB], [https://www.ebi.ac.uk/pdbsum/4qkv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qkv ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CAVN1_MOUSE CAVN1_MOUSE] Plays an important role in caveolae formation and organization. Essential for the formation of caveolae in all tissues (PubMed:18191225, PubMed:18840361, PubMed:18056712, PubMed:30188967). Core component of the CAVIN complex which is essential for recruitment of the complex to the caveolae in presence of calveolin-1 (CAV1) (PubMed:19546242). Essential for normal oligomerization of CAV1 (PubMed:23652019). Promotes ribosomal transcriptional activity in response to metabolic challenges in the adipocytes and plays an important role in the formation of the ribosomal transcriptional loop (PubMed:27528195). Dissociates transcription complexes paused by DNA-bound TTF1, thereby releasing both RNA polymerase I and pre-RNA from the template (PubMed:9582279, PubMed:11139612). The caveolae biogenesis pathway is required for the secretion of proteins such as GASK1A (PubMed:30188967).<ref>PMID:11139612</ref> <ref>PMID:18056712</ref> <ref>PMID:18191225</ref> <ref>PMID:18840361</ref> <ref>PMID:19546242</ref> <ref>PMID:23652019</ref> <ref>PMID:27528195</ref> <ref>PMID:30188967</ref> <ref>PMID:9582279</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Collins BM]]
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[[Category: Kovtun O]]
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[[Category: Parton RG]]
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[[Category: Tillu V]]

Current revision

Crystal structure of the mouse cavin1 HR1 domain

PDB ID 4qkv

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