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4cyj
From Proteopedia
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==Chaetomium thermophilum Pan2:Pan3 complex== | ==Chaetomium thermophilum Pan2:Pan3 complex== | ||
| - | <StructureSection load='4cyj' size='340' side='right' caption='[[4cyj]], [[Resolution|resolution]] 2.59Å' scene=''> | + | <StructureSection load='4cyj' size='340' side='right'caption='[[4cyj]], [[Resolution|resolution]] 2.59Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4cyj]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CYJ OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[4cyj]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Chaetomium_thermophilum Chaetomium thermophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CYJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CYJ FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cyj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cyj OCA], [https://pdbe.org/4cyj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cyj RCSB], [https://www.ebi.ac.uk/pdbsum/4cyj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cyj ProSAT]</span></td></tr> | |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </table> |
| - | <table> | + | == Function == |
| + | [[https://www.uniprot.org/uniprot/PAN3_CHATD PAN3_CHATD]] Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and with PAB1.[HAMAP-Rule:MF_03181]<ref>PMID:24872509</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 4cyj" style="background-color:#fffaf0;"></div> | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Allen | + | [[Category: Chaetomium thermophilum]] |
| - | [[Category: Bycroft | + | [[Category: Large Structures]] |
| - | [[Category: Gordiyenko | + | [[Category: Allen MD]] |
| - | [[Category: McLaughlin | + | [[Category: Bycroft M]] |
| - | [[Category: Meineke | + | [[Category: Gordiyenko Y]] |
| - | [[Category: Olsen | + | [[Category: McLaughlin SH]] |
| - | [[Category: Passmore | + | [[Category: Meineke B]] |
| - | [[Category: Robinson | + | [[Category: Olsen TM]] |
| - | [[Category: Stewart | + | [[Category: Passmore LA]] |
| - | [[Category: Valkov | + | [[Category: Robinson CV]] |
| - | [[Category: Wolf | + | [[Category: Stewart M]] |
| - | + | [[Category: Valkov E]] | |
| - | + | [[Category: Wolf J]] | |
Current revision
Chaetomium thermophilum Pan2:Pan3 complex
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