4qm0
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4qm0 is ON HOLD Authors: Boenig, G., Hymowitz, S.G., Wang, W. Description: Crystal structure of RORc in complex with a tertiary sulfonamide inverse...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of RORc in complex with a tertiary sulfonamide inverse agonist== | |
| - | + | <StructureSection load='4qm0' size='340' side='right'caption='[[4qm0]], [[Resolution|resolution]] 2.19Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4qm0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QM0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QM0 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.195Å</td></tr> | |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=39K:N-(2-METHYLPROPYL)-N-({5-[4-(METHYLSULFONYL)PHENYL]THIOPHEN-2-YL}METHYL)-1-PHENYLMETHANESULFONAMIDE'>39K</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qm0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qm0 OCA], [https://pdbe.org/4qm0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qm0 RCSB], [https://www.ebi.ac.uk/pdbsum/4qm0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qm0 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Boenig G]] | ||
| + | [[Category: Hymowitz SG]] | ||
| + | [[Category: Wang W]] | ||
Current revision
Crystal structure of RORc in complex with a tertiary sulfonamide inverse agonist
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