This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2mqk
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 2mqk is ON HOLD Authors: Lopez-Mendez, B., Dramicanin, M., Campos-Olivas, R., Ramon-Maiques, S. Description: Solution structure of N terminal domai...) |
|||
| (8 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Solution structure of N terminal domain of the MuB AAA+ ATPase== | |
| - | + | <StructureSection load='2mqk' size='340' side='right'caption='[[2mqk]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2mqk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_Mu Escherichia virus Mu]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MQK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MQK FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mqk OCA], [https://pdbe.org/2mqk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mqk RCSB], [https://www.ebi.ac.uk/pdbsum/2mqk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mqk ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TARGB_BPMU TARGB_BPMU] Selects the target DNA sites for transposition. Recruits DDE-recombinase A to the target sites and catalytically activates it. Displays non-specific DNA-binding properties. Polymerizes as helical filaments around the DNA. Coating of the DNA by the target DNA activator B might play a role in favoring target-primed replication over integration. Prevents self-integration into an integrated copy of the viral genome. This mechanism is called target immunity and is achieved by two mechanisms: first, the target DNA activator B dissociates from the viral genome ends upon interaction in cis with DDE-recombinase A, which makes the viral genome ends a poor target for new insertions. Second, the interior of the viral genome may also ne protected from integration events by the target DNA activator B being strongly bound throughout the whole viral genome.<ref>PMID:11298282</ref> <ref>PMID:14661976</ref> <ref>PMID:1646076</ref> <ref>PMID:17709741</ref> <ref>PMID:17988683</ref> <ref>PMID:20226074</ref> <ref>PMID:23776210</ref> <ref>PMID:24478936</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Escherichia virus Mu]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Campos-Olivas R]] | ||
| + | [[Category: Dramicanin M]] | ||
| + | [[Category: Lopez-Mendez B]] | ||
| + | [[Category: Ramon-Maiques S]] | ||
Current revision
Solution structure of N terminal domain of the MuB AAA+ ATPase
| |||||||||||
