2mqk

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'''Unreleased structure'''
 
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The entry 2mqk is ON HOLD
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==Solution structure of N terminal domain of the MuB AAA+ ATPase==
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<StructureSection load='2mqk' size='340' side='right'caption='[[2mqk]]' scene=''>
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Authors: Lopez-Mendez, B., Dramicanin, M., Campos-Olivas, R., Ramon-Maiques, S.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2mqk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_Mu Escherichia virus Mu]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MQK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MQK FirstGlance]. <br>
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Description: Solution structure of N terminal domain of the MuB AAA+ ATPase
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mqk OCA], [https://pdbe.org/2mqk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mqk RCSB], [https://www.ebi.ac.uk/pdbsum/2mqk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mqk ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TARGB_BPMU TARGB_BPMU] Selects the target DNA sites for transposition. Recruits DDE-recombinase A to the target sites and catalytically activates it. Displays non-specific DNA-binding properties. Polymerizes as helical filaments around the DNA. Coating of the DNA by the target DNA activator B might play a role in favoring target-primed replication over integration. Prevents self-integration into an integrated copy of the viral genome. This mechanism is called target immunity and is achieved by two mechanisms: first, the target DNA activator B dissociates from the viral genome ends upon interaction in cis with DDE-recombinase A, which makes the viral genome ends a poor target for new insertions. Second, the interior of the viral genome may also ne protected from integration events by the target DNA activator B being strongly bound throughout the whole viral genome.<ref>PMID:11298282</ref> <ref>PMID:14661976</ref> <ref>PMID:1646076</ref> <ref>PMID:17709741</ref> <ref>PMID:17988683</ref> <ref>PMID:20226074</ref> <ref>PMID:23776210</ref> <ref>PMID:24478936</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Escherichia virus Mu]]
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[[Category: Large Structures]]
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[[Category: Campos-Olivas R]]
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[[Category: Dramicanin M]]
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[[Category: Lopez-Mendez B]]
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[[Category: Ramon-Maiques S]]

Current revision

Solution structure of N terminal domain of the MuB AAA+ ATPase

PDB ID 2mqk

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