4qpj
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==2.7 Angstrom Structure of a Phosphotransferase in Complex with a Receiver Domain== | |
| + | <StructureSection load='4qpj' size='340' side='right'caption='[[4qpj]], [[Resolution|resolution]] 2.74Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4qpj]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Brucella_abortus_2308 Brucella abortus 2308]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QPJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QPJ FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.742Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qpj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qpj OCA], [https://pdbe.org/4qpj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qpj RCSB], [https://www.ebi.ac.uk/pdbsum/4qpj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qpj ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CHPT_BRUA2 CHPT_BRUA2] Component of a regulatory phosphorelay system that controls B.abortus cell growth, division, and intracellular survival inside mammalian host cells. This signaling pathway is composed of CckA, ChpT, CtrA and CpdR. ChpT efficiently and specifically shuttles phosphoryl groups from the CckA kinase to the receiver domains of both CtrA and CpdR. Does not bind ATP. Overexpression of chpT results in a defect in cell morphology, DNA content, and intracellular survival in human macrophages.<ref>PMID:26124143</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Phosphotransferase 3D structures|Phosphotransferase 3D structures]] | |
| - | + | *[[Response regulator 3D structure|Response regulator 3D structure]] | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Brucella abortus 2308]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Crosson S]] | ||
| + | [[Category: Herrou J]] | ||
| + | [[Category: Willett JW]] | ||
Current revision
2.7 Angstrom Structure of a Phosphotransferase in Complex with a Receiver Domain
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