4psq

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==Crystal Structure of Retinol-Binding Protein 4 (RBP4) in complex with a non-retinoid ligand==
==Crystal Structure of Retinol-Binding Protein 4 (RBP4) in complex with a non-retinoid ligand==
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<StructureSection load='4psq' size='340' side='right' caption='[[4psq]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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<StructureSection load='4psq' size='340' side='right'caption='[[4psq]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4psq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PSQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PSQ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4psq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PSQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PSQ FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2WL:(1-BENZYL-1H-IMIDAZOL-4-YL)[4-(2-CHLOROPHENYL)PIPERAZIN-1-YL]METHANONE'>2WL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3fmz|3fmz]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2WL:(1-BENZYL-1H-IMIDAZOL-4-YL)[4-(2-CHLOROPHENYL)PIPERAZIN-1-YL]METHANONE'>2WL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4psq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4psq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4psq RCSB], [http://www.ebi.ac.uk/pdbsum/4psq PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4psq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4psq OCA], [https://pdbe.org/4psq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4psq RCSB], [https://www.ebi.ac.uk/pdbsum/4psq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4psq ProSAT]</span></td></tr>
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<table>
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</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/RET4_HUMAN RET4_HUMAN]] Defects in RBP4 are a cause of retinol-binding protein deficiency (RBP deficiency) [MIM:[http://omim.org/entry/180250 180250]]. This condition causes night vision problems. It produces a typical 'fundus xerophthalmicus', featuring a progressed atrophy of the retinal pigment epithelium.
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[https://www.uniprot.org/uniprot/RET4_HUMAN RET4_HUMAN] Defects in RBP4 are a cause of retinol-binding protein deficiency (RBP deficiency) [MIM:[https://omim.org/entry/180250 180250]. This condition causes night vision problems. It produces a typical 'fundus xerophthalmicus', featuring a progressed atrophy of the retinal pigment epithelium.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RET4_HUMAN RET4_HUMAN]] Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.
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[https://www.uniprot.org/uniprot/RET4_HUMAN RET4_HUMAN] Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4psq" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Retinol-binding protein 3D structures|Retinol-binding protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Johnstone, S.]]
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[[Category: Homo sapiens]]
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[[Category: Walker, N.]]
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[[Category: Large Structures]]
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[[Category: Wang, Z.]]
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[[Category: Johnstone S]]
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[[Category: Disease mutation]]
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[[Category: Walker N]]
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[[Category: Retinol binding]]
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[[Category: Wang Z]]
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[[Category: Secreted]]
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[[Category: Sensory transduction]]
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[[Category: Transport protein]]
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[[Category: Vision]]
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[[Category: Vitamin some]]
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Current revision

Crystal Structure of Retinol-Binding Protein 4 (RBP4) in complex with a non-retinoid ligand

PDB ID 4psq

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